化学物質有害性情報データベース 物質情報

CAS 登録番号 CAS RN® : 21564170
官報公示整理番号 METI No. : 9-1291
物質名 test material : 2-[(チオシアナトメチル)スルファニル]-1,3-ベンゾチアゾール /2-[(Thiocyanatomethyl)sulfanyl]-1,3-benzothiazole
水溶解度 water solubility
LogKow : 3.3 (実測値 measured)
備考 remarks
Excelファイルダウンロード (XLS:21KB)

【注意事項】
* 化学物質有害性情報データベース情報更新日が2019年9月以前はRead-acrossデータでも○としていないので、毒性値の取り扱いには注意が必要である。

                       
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) Read-across * QSAR GLP 設定濃度 実測濃度 情報源 情報源による信頼性評価 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure duration value exposure duration unit toxicity value toxicity unit Read-across QSAR GLPnominal concentration measured concentrationoriginal work type original work reliability rankauthor title referenced journal publication year Information update date
藻類 Pseudokirchneriella subcapitata Population LOEC 1.25 days 29 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fernandez-Alba,A.R., M.D. Hernando, L. Piedra, and Y. Chisti Toxicity Evaluation of Single and Mixed Antifouling Biocides Measured with Acute Toxicity Bioassays Anal. Chim. Acta456(2): 303-312 2002 2017/03/15
藻類 Pseudokirchneriella subcapitata Population EC50 3 days 430 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Mezcua,M., M.D. Hernando, L. Piedra, A. Aguera, and A.R. Fernandez-Alba Chromatography-Mass Spectrometry and Toxicity Evaluation of Selected Contaminants in Seawater Chromatographia (Wiesb.)56(3/4): 199-206 2002 2017/03/15
藻類 Pseudokirchneriella subcapitata Population LOEC 3 days 150 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Mezcua,M., M.D. Hernando, L. Piedra, A. Aguera, and A.R. Fernandez-Alba Chromatography-Mass Spectrometry and Toxicity Evaluation of Selected Contaminants in Seawater Chromatographia (Wiesb.)56(3/4): 199-206 2002 2017/03/15
藻類 Pseudokirchneriella subcapitata Population EC50 3 days 430 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fernandez-Alba,A.R., L. Piedra, M. Mezcua, and M.D. Hernando Toxicity of Single and Mixed Contaminants in Seawater Measured with Acute Toxicity Bioassays Sci. World J.2:1115-1120 2002 2017/03/15
藻類 Pseudokirchneriella subcapitata Population EC50 1.25 days 39 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fernandez-Alba,A.R., M.D. Hernando, L. Piedra, and Y. Chisti Toxicity Evaluation of Single and Mixed Antifouling Biocides Measured with Acute Toxicity Bioassays Anal. Chim. Acta456(2): 303-312 2002 2017/03/15
藻類 Pseudokirchneriella subcapitata Population EC50 3 days 433 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Hernando,M.D., A.R. Fernandez-Alba, R. Tauler, and D. Barcelo Toxicity Assays Applied to Wastewater Treatment Talanta65(2): 358-366 2005 2017/03/15
藻類 Pseudokirchneriella subcapitata Population LOEC 3 days 150 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Hernando,M.D., A.R. Fernandez-Alba, R. Tauler, and D. Barcelo Toxicity Assays Applied to Wastewater Treatment Talanta65(2): 358-366 2005 2017/03/15
藻類 Pseudokirchneriella subcapitata EC50 96 hours 250 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
藻類 Navicula pelliculosa EC50 96 hours 40 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
藻類 Anabaena flos-aquae EC50 96 hours 156 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2014 2017/03/01
藻類 Navicula pelliculosa NOEL 96 hours 24 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
藻類 Anabaena flos-aquae NOEL 96 hours 116 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2014 2017/03/01
藻類 Pseudokirchneriella subcapitata NOEL 96 hours 29.3 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
甲殻類 Daphnia magna LOEC 21 days 1.8 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Ceriodaphnia dubia Mortality 7 days 5.6 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Ceriodaphnia dubia Mortality 2 days 5.5 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Ceriodaphnia dubia Mortality 2 days 23 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Daphnia magna Physiology NOEL 2 days 8.7 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Daphnia magna Physiology NOEL 2 days <13 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Ceriodaphnia dubia Reproduction NOEC 7 days 2.5 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Ceriodaphnia dubia Reproduction LOEL 7 days 5.6 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Daphnia magna Physiology LOEC 2 days 21 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Hernando,M.D., A.R. Fernandez-Alba, R. Tauler, and D. Barcelo Toxicity Assays Applied to Wastewater Treatment Talanta65(2): 358-366 2005 2017/03/15
甲殻類 Ceriodaphnia dubia Mortality EC50 2 days 15.3 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Daphnia magna Physiology EC50 2 days 23 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Daphnia magna Physiology EC50 2 days 46 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fernandez-Alba,A.R., L. Piedra, M. Mezcua, and M.D. Hernando Toxicity of Single and Mixed Contaminants in Seawater Measured with Acute Toxicity Bioassays Sci. World J.2:1115-1120 2002 2017/03/15
甲殻類 Daphnia magna Physiology EC50 2 days 23 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Daphnia magna Physiology EC50 2 days 46 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Hernando,M.D., A.R. Fernandez-Alba, R. Tauler, and D. Barcelo Toxicity Assays Applied to Wastewater Treatment Talanta65(2): 358-366 2005 2017/03/15
甲殻類 Ceriodaphnia dubia Mortality EC50 7 days 5.6 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nawrocki,S.T., K.D. Drake, C.F. Watson, G.D. Foster, and K.J. Maier Comparative Aquatic Toxicity Evaluation of 2-(Thiocyanomethylthio)benzothiazole and Selected Degradation Products Using Ceriodaphnia dubia Arch. Environ. Contam. Toxicol.48(3): 344-350 2005 2017/03/15
甲殻類 Daphnia magna NOEC 21 days 0.89 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Daphnia magna EC50 48 hours 23 μg/L 3 USEPA Pesticide Ecotoxicity Database J. Hopkins 1979 2017/03/01
甲殻類 Daphnia magna EC50 48 hours 23.1 μg/L 3 USEPA Pesticide Ecotoxicity Database R. Lamb 1991 2017/03/01
甲殻類 Daphnia magna NOEL 48 hours 8.7 μg/L 3 USEPA Pesticide Ecotoxicity Database R. Lamb 1991 2017/03/01
甲殻類 Daphnia magna LOEC 21 days 1.8 μg/L 3 USEPA Pesticide Ecotoxicity Database Srinivas Gowda 2001 2017/03/01
甲殻類 Daphnia magna NOEL 48 hours 13 μg/L 3 USEPA Pesticide Ecotoxicity Database J. Hopkins 1979 2017/03/01
甲殻類 Daphnia magna NOEL 21 days 0.89 μg/L 3 USEPA Pesticide Ecotoxicity Database Srinivas Gowda 2001 2017/03/01
甲殻類 Daphnia magna GROWTH LOEC 21 days 1.8 ppb 3 USEPA Pesticide Ecotoxicity Database Srinivas Gowda 2001 2018/03/09
甲殻類 Daphnia magna GROWTH NOEL 21 days 0.89 ppb 3 USEPA Pesticide Ecotoxicity Database Srinivas Gowda 2001 2018/03/09
魚類 Oncorhynchus mykiss (Rainbow trout) Growth LOEC 60 days 0.56 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality LC50 4 days 32 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality NOEL 4 days 27 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Growth NOEC 60 days 0.34 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Reproduction LOEC 60 days 2.4 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC50 4 days 20.12 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC50 4 days 45 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC50 4 days 29 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality NOEL 4 days 8.7 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality NOEL 4 days 16 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality LC50 4 days 8.7 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality LC50 4 days 47 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Danio rerio (Zebrafish) EC50 5 days 0.432 μM 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Padilla,S., D. Corum, B. Padnos, D.L. Hunter, A. Beam, K.A. Houck, N. Sipes, N. Kleinstreuer, T. Knudsen, D.J. Dix, and Zebrafish Developmental Screening of the ToxCast Phase I Chemical Library Reprod. Toxicol.33(2): 174-187 2012 2017/03/15
魚類 Danio rerio (Zebrafish) EC10 5 days 0.3608 μM 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Padilla,S., D. Corum, B. Padnos, D.L. Hunter, A. Beam, K.A. Houck, N. Sipes, N. Kleinstreuer, T. Knudsen, D.J. Dix, and Zebrafish Developmental Screening of the ToxCast Phase I Chemical Library Reprod. Toxicol.33(2): 174-187 2012 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC50 2 days 21 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Waller,D.L., J.J. Rach, W.G. Cope, L.L. Marking, S.W. Fisher, and H. Dabrowska Toxicity of Candidate Molluscicides to Zebra Mussels (Dreissena polymorpha) and Selected Nontarget Organisms J. Great Lakes Res.19(4): 695-702 1993 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality NOEL 4 days 5.1 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 29 μg/L 3 USEPA Pesticide Ecotoxicity Database J. Tice 1968 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 20.12 μg/L 3 USEPA Pesticide Ecotoxicity Database D. Lateulere 1992 2017/03/01
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 47 μg/L 3 USEPA Pesticide Ecotoxicity Database J. Tice 1968 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 220 μg/L 3 USEPA Pesticide Ecotoxicity Database B. Montague 2004 2017/03/01
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 1000 μg/L 3 USEPA Pesticide Ecotoxicity Database B. Montague 2004 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 45 μg/L 3 USEPA Pesticide Ecotoxicity Database S. Palmateer 1980 2017/03/01
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 32 μg/L 3 USEPA Pesticide Ecotoxicity Database S. Palmateer 1980 2017/03/01
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 8.73 μg/L 3 USEPA Pesticide Ecotoxicity Database R. Lamb 1991 2017/03/01
魚類 Cyprinodon variegatus (Sheepshead minnow) LC50 96 hours 60 μg/L 3 USEPA Pesticide Ecotoxicity Database M. Roberts 1991 2017/03/01
魚類 Oryzias latipes (Japanese medaka) Mortality LC50 48 hours 0.0994 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) - Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan Chemicals Investigation and Testing Institute. 1992. Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan, ISBN 4-98074-101-1. Japan Chemical Industry Ecology-Toxicology&Information Center; 1992 2017/03/22
魚類 Oncorhynchus mykiss (Rainbow trout) LOEC 60 days 0.56 μg/L 3 USEPA Pesticide Ecotoxicity Database D. Lateulere 1993 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) NOEL 96 hours 8.7 μg/L 3 USEPA Pesticide Ecotoxicity Database D. Lateulere 1992 2017/03/01
魚類 Cyprinodon variegatus (Sheepshead minnow) NOEL 96 hours 36 μg/L 3 USEPA Pesticide Ecotoxicity Database M. Roberts 1991 2017/03/01
魚類 Lepomis macrochirus (Bluegill) NOEL 96 hours 5.1 μg/L 3 USEPA Pesticide Ecotoxicity Database R. Lamb 1991 2017/03/01
魚類 Lepomis macrochirus (Bluegill) NOEL 96 hours 16 μg/L 3 USEPA Pesticide Ecotoxicity Database S. Palmateer 1980 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) NOEL 96 hours 27 μg/L 3 USEPA Pesticide Ecotoxicity Database S. Palmateer 1980 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) NOEL 96 hours <100 μg/L 3 USEPA Pesticide Ecotoxicity Database B. Montague 2004 2017/03/01
魚類 Lepomis macrochirus (Bluegill) NOEL 96 hours 750 μg/L 3 USEPA Pesticide Ecotoxicity Database B. Montague 2004 2017/03/01
魚類 Pimephales promelas (Fathead minnow) LOEC 33 days 2.6 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
魚類 Pimephales promelas (Fathead minnow) NOEL 33 days 1 μg/L 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2017/03/01
魚類 Oncorhynchus mykiss (Rainbow trout) NOEL 60 days 0.34 μg/L 3 USEPA Pesticide Ecotoxicity Database D. Lateulere 1993 2017/03/01
魚類 Pimephales promelas (Fathead minnow) SURVIVE, GROWTH LOEC 33 days 2.6 ppb 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2018/03/09
魚類 Pimephales promelas (Fathead minnow) SURVIVE, GROWTH NOEL 33 days 1 ppb 3 USEPA Pesticide Ecotoxicity Database W. Erickson 2013 2018/03/09