生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 107-46-0
官報公示整理番号　METI No. ： 2-2956
物質名 test material ： ヘキサメチルジシロキサン　／Disiloxane, hexamethyl-
水溶解度 water solubility ： 0.93mg/L (推計値 estimated)
LogKow ： 5.25 (推計値 estimated)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Selenastrum capricornutum growth rate ErC10 70 hours 0.09 mg/L 12 ECHA Information on Registered Substances 2018/02/05
藻類 Pseudokirchneriella subcapitata growth rate 70 hours 0.01 mg/L ○ 4 OECD SIDS (HPVC) 2 Oldersma H., Hantsveit A.O. and Rooseboom-Reimers A. Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum|capricornutum. 2003 2018/03/10
藻類 Desmodesmus subspicatus growth rate EC50 72 hours >32 mg/L silicon concentration ○ 4 OECD SIDS (HPVC) 4 Huls Infracor GmbH Siliconol NM 1-0.65 Algae Growth Inhibition 86.81.SAG (Algae growth inhibition|following EG 92/69/EEC). Huls Infracor, Marl, Germany 1999 2018/03/10
藻類 Pseudokirchneriella subcapitata biomass EC50 95 hours 0.22 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Desmodesmus subspicatus growth rate EC50 72 hours >=1000 mg/L ○ 4 OECD SIDS (HPVC) 4 Huls Infracor GmbH Siliconol NM 1-0.65 Algae Growth Inhibition 86.81.SAG (Algae growth inhibition|following EG 92/69/EEC). Huls Infracor, Marl, Germany 1999 2018/03/10
藻類 Desmodesmus subspicatus growth rate EC50 72 hours >1000 mg/L ○ 4 OECD SIDS (HPVC) 4 Huls Infracor GmbH Siliconol NM 1-0.65 Algae Growth Inhibition 86.81.SAG (Algae growth inhibition|following EG 92/69/EEC). Huls Infracor, Marl, Germany 1999 2018/03/10
藻類 Pseudokirchneriella subcapitata biomass EbC50 95 hours 0.22 mg/L 4 OECD SIDS (HPVC) 2018/03/09
藻類 Pseudokirchneriella subcapitata growth rate ErC50 70 hours >0.55 mg/L 4 OECD SIDS (HPVC) 2018/03/09
藻類 Pseudokirchneriella subcapitata growth rate EC50 95 hours >0.55 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Selenastrum capricornutum growth rate ErC50 70 hours >0.55 mg/L 12 ECHA Information on Registered Substances 2018/02/05
藻類 Pseudokirchneriella subcapitata growth rate ErC50 95 hours >0.55 mg/L 4 OECD SIDS (HPVC) 2018/03/09
藻類 Pseudokirchneriella subcapitata growth rate EC50 70 hours >0.55 mg/L ○ 4 OECD SIDS (HPVC) 2 Oldersma H., Hantsveit A.O. and Rooseboom-Reimers A. Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum|capricornutum. 2003 2018/03/10
藻類 Pseudokirchneriella subcapitata growth rate LOEC 95 hours 0.28 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Desmodesmus subspicatus growth rate NOEC 72 hours >=32 mg/L silicon concentration ○ 4 OECD SIDS (HPVC) 4 Huls Infracor GmbH Siliconol NM 1-0.65 Algae Growth Inhibition 86.81.SAG (Algae growth inhibition|following EG 92/69/EEC). Huls Infracor, Marl, Germany 1999 2018/03/10
藻類 Pseudokirchneriella subcapitata growth rate EC10 95 hours 0.14 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Pseudokirchneriella subcapitata growth rate LOEC 95 hours 0.28 mg/L 4 OECD SIDS (HPVC) 2018/03/09
藻類 Pseudokirchneriella subcapitata growth rate NOEC 70 hours 0.1 mg/L 4 OECD SIDS (HPVC) 2018/03/09
藻類 Pseudokirchneriella subcapitata growth rate NOEC 95 hours 0.15 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Pseudokirchneriella subcapitata biomass EC10 95 hours 0.05 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum capricornutum. TNO. Zeist, NL.., Centre Europeen des Silicones 2003 2018/03/10
藻類 Pseudokirchneriella subcapitata growth rate EC10 70 hours 0.009 mg/L ○ 4 OECD SIDS (HPVC) 2 Oldersma H., Hantsveit A.O. and Rooseboom-Reimers A. Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrum|capricornutum. 2003 2018/03/10
藻類 Pseudokirchneriella subcapitata growth rate NOEC 95 hours 0.15 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna mobility NOEC 48 hours >=0.37 mg/L ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility EC50 48 hours >11 mg/L silicon content ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility NOELR 48 hours >=1000 mg/L ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility EL50 48 hours >1000 mg/L ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility NOEC 48 hours >=11 mg/L silicon content ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility EC50 48 hours >0.37 mg/L ○ 4 OECD SIDS (HPVC) 3 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to daphnia (Acute toxicity to daphnia test following EG 92/69/EEC). Hils Infracor GmbH 1999 2018/03/10
甲殻類 Daphnia magna mobility EC100 24 hours >400 mg/L × 4 OECD SIDS (HPVC) 4 Bayer AG Internal Company data 1988 2018/03/10
甲殻類 Daphnia magna mobility NOEC 24 hours ca.31.4 mg/L 4 OECD SIDS (HPVC) 4 Grau Internal report. Bayer AG 1991 2018/03/10
甲殻類 Daphnia magna mobility EC0 24 hours 50 mg/L × 4 OECD SIDS (HPVC) 4 Bayer AG Internal Company data 1988 2018/03/10
甲殻類 Daphnia magna mobility EC50 24 hours ca.314 mg/L 4 OECD SIDS (HPVC) 4 Grau Internal report. Bayer AG 1991 2018/03/10
甲殻類 Daphnia magna reproduction EC50 21 days 0.3 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna reproduction LOEC 21 days 0.14 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna reproduction NOEC 21 days 0.08 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna reproduction NOEC 21 days 0.08 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna condition NOEC 21 days 0.25 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna condition LOEC 21 days 0.44 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna condition NOEC 21 days 0.25 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna EC50 21 days 0.45 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna mortality NOEC 21 days 0.25 mg/L 4 OECD SIDS (HPVC) 2018/03/09
甲殻類 Daphnia magna mortality NOEC 21 days 0.25 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna mortality LC50 21 days 0.45 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna condition LOEC 21 days 0.44 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna mortality LOEC 21 days 0.44 mg/L ○ 4 OECD SIDS (HPVC) 2 TNO Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). TNO, Zeist, The Netherlands 1988 2018/03/10
甲殻類 Daphnia magna reproduction NOEC 21 days 0.08 mg/L 12 ECHA Information on Registered Substances 2018/02/05
甲殻類 Daphnia magna reproduction EC50 21 days 0.3 mg/L 12 ECHA Information on Registered Substances 2018/02/05
甲殻類 Daphnia magna reproduction LOEC 21 days 0.14 mg/L 4 OECD SIDS (HPVC) 2018/03/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 96 hours 3.02 mg/L 12 ECHA Information on Registered Substances 2018/02/05
魚類 Oncorhynchus mykiss (Rainbow trout) mortality NOEC 96 hours 0.28 mg/L 12 ECHA Information on Registered Substances 2018/02/05
魚類 Cyprinus carpio (Carp) mortality LL50 96 hours >1000 mg/L ○ 4 OECD SIDS (HPVC) 4 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to fish (Acute toxicity to fish test following EG 92/69/EWG EEC). Degussa-Huls AG , FK 1401. Degussa-Huls AG-Nr.: 99-0065-DGO 1999 2018/03/10
魚類 Cyprinus carpio (Carp) mortality LC50 96 hours >13.5 mg/L silicon content ○ 4 OECD SIDS (HPVC) 4 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to fish (Acute toxicity to fish test following EG 92/69/EWG EEC). Degussa-Huls AG , FK 1401. Degussa-Huls AG-Nr.: 99-0065-DGO 1999 2018/03/10
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 14 days >=0.093 mg/L ○ 4 OECD SIDS (HPVC) 2 Annelin, R.B. and J.L. Hamelink A fourteen day aquatic toxicity test of hexamethyl disiloxane in fathead minnow under flow-through saturated conditions. Dow Corning Corporation 1990 2018/03/10
魚類 Oryzias latipes (Japanese medaka) mortality LC50 48 hours 1.27 mg/L ○ 4 OECD SIDS (HPVC) 2 Matsunobu, Y. Bioaccumulation test of LS-7130 in Carp Kurume Research Laboratories, Japan 1995 2018/03/10
魚類 Cyprinus carpio (Carp) mortality NOELR 96 hours >=1000 mg/L ○ 4 OECD SIDS (HPVC) 4 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to fish (Acute toxicity to fish test following EG 92/69/EWG EEC). Degussa-Huls AG , FK 1401. Degussa-Huls AG-Nr.: 99-0065-DGO 1999 2018/03/10
魚類 Pimephales promelas (Fathead minnow) LC50 14 days >0.093 mg/L 4 OECD SIDS (HPVC) 2018/03/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 96 hours 3.02 mg/L ○ 4 OECD SIDS (HPVC) 2 Bayer AG Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. Bayer AG. internal report. FF-313 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) mortality NOEC 96 hours 0.28 mg/L ○ 4 OECD SIDS (HPVC) 2 Bayer AG Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. Bayer AG. internal report. FF-313 2018/03/10
魚類 Oryzias latipes (Japanese medaka) mortality NOEC 48 hours 0.639 mg/L ○ 4 OECD SIDS (HPVC) 2 Matsunobu, Y. Bioaccumulation test of LS-7130 in Carp Kurume Research Laboratories, Japan 1995 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) mortality NOEC 9 days >=0.095 mg/L ○ 4 OECD SIDS (HPVC) 4 Dow Corning Corporation An Attempt to Access the Lethal Body Burden of Me3SiOSiMe3 to Rainbow Trout 1990 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 9 days >0.095 mg/L ○ 4 OECD SIDS (HPVC) 4 Dow Corning Corporation An Attempt to Access the Lethal Body Burden of Me3SiOSiMe3 to Rainbow Trout 1990 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 0.46 mg/L 4 OECD SIDS (HPVC) 2018/03/09
魚類 Pimephales promelas (Fathead minnow) mortality LC50 14 days >0.093 mg/L ○ 4 OECD SIDS (HPVC) 2 Annelin, R.B. and J.L. Hamelink A fourteen day aquatic toxicity test of hexamethyl disiloxane in fathead minnow under flow-through saturated conditions. Dow Corning Corporation 1990 2018/03/10
魚類 Cyprinus carpio (Carp) mortality NOEC 96 hours >=13.5 mg/L silicon content ○ 4 OECD SIDS (HPVC) 4 Huls Infracor Siliconol NM 1-0.65 Determination of the acute toxicity to fish (Acute toxicity to fish test following EG 92/69/EWG EEC). Degussa-Huls AG , FK 1401. Degussa-Huls AG-Nr.: 99-0065-DGO 1999 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 96 hours 0.46 mg/L ○ 4 OECD SIDS (HPVC) 2 Bayer AG Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. Bayer AG. internal report. FF-313 2018/03/10
魚類 Oncorhynchus mykiss (Rainbow trout) embryo survival, larval hatch and growth (length and dry weight) NOEC 90 days >=27 μg/L 12 ECHA Information on Registered Substances Springborn Smithers 2010 2018/03/03
魚類 Cyprinus carpio (Carp) mortality, behaviour and appearance NOEC 10 weeks >=2.4 μg/L ○ 4 OECD SIDS (HPVC) 3 Kurume Research Laboratories Bioaccumulation test of LS-7130 in Carp. Kurume Research Laboratories, Japan 1995 2018/03/10
魚類 Cyprinus carpio (Carp) mortality, behaviour and appearance NOEC 8 weeks >=40 μg/L ○ 4 OECD SIDS (HPVC) 3 Kurume Research Laboratories Bioaccumulation test of LS-7130 in Carp. Kurume Research Laboratories, Japan 1995 2018/03/10