生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 108-10-1
官報公示整理番号　METI No. ： 2-542
物質名 test material ： メチルイソブチルケトン　／Methyl isobutyl ketone
水溶解度 water solubility ： 19000mg/L (推計値 estimated)
LogKow ： 1.31 (実測値 measured)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Scenedesmus subspicatus Population EC50 2 days 980000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
藻類 Scenedesmus subspicatus Cellular Effects EC3 7 days 1430000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Trenel,J., and R. Kuhn Bewertung Wassergefahrdender Stoffe im Hinblick
auf Lagerung, Umschlag und Transport		 Umweltforschungsplan des Bundesministers des
Innern:		 1982 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 2 days 2000000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
甲殻類 Daphnia magna Behavior EC50 1 days 3623000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Behavior EC50 1 days 3200000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Trenel,J., and R. Kuhn Bewertung Wassergefahrdender Stoffe im Hinblick
auf Lagerung, Umschlag und Transport		 Umweltforschungsplan des Bundesministers des
Innern:		 1982 2016/03/25
甲殻類 Daphnia magna Reproduction NOEC 21 days 7800～39000 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4): 501-510 1989 2016/03/25
甲殻類 Daphnia magna Behavior NOEC 21 days 78000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Behavior EC100 1 days 5000000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuehn Results of Toxic Action of Water Pollutants on
Daphnia magna Straus Tested by an Improved
Standardized Procedure		 Z. Wasser-Abwasser-Forsch.15(1): 1-6 1982 2016/03/25
甲殻類 Daphnia magna Physiology EC50 1 days 3682000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4): 501-510 1989 2016/03/25
甲殻類 Daphnia magna Behavior EC0 1 days 930000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Physiology LC100 1 days 5000000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuhn Results of the Damaging Effect of Water
Pollutants on Daphnia magna (Befunde der
Schadwirkung Wassergefahrdender
Stoffe Gegen Daphnia magna)		 TR-79-1204, Literature Research Company,
Annandale, VA:26 p.		 1977 2016/03/25
甲殻類 Daphnia magna Physiology LC0 1 days 2280000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuhn Results of the Damaging Effect of Water
Pollutants on Daphnia magna (Befunde der
Schadwirkung Wassergefahrdender
Stoffe Gegen Daphnia magna)		 TR-79-1204, Literature Research Company,
Annandale, VA:26 p.		 1977 2016/03/25
甲殻類 Daphnia magna Physiology LC50 1 days 4280000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuhn Results of the Damaging Effect of Water
Pollutants on Daphnia magna (Befunde der
Schadwirkung Wassergefahrdender
Stoffe Gegen Daphnia magna)		 TR-79-1204, Literature Research Company,
Annandale, VA:26 p.		 1977 2016/03/25
甲殻類 Daphnia magna Behavior EC50 1 days 1550000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuehn Results of Toxic Action of Water Pollutants on
Daphnia magna Straus Tested by an Improved
Standardized Procedure		 Z. Wasser-Abwasser-Forsch.15(1): 1-6 1982 2016/03/25
甲殻類 Daphnia magna Behavior EC0 1 days 474000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bringmann,G., and R. Kuehn Results of Toxic Action of Water Pollutants on
Daphnia magna Straus Tested by an Improved
Standardized Procedure		 Z. Wasser-Abwasser-Forsch.15(1): 1-6 1982 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth LOEC 105000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth LOEC 105000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 505000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Brooke,L.T., D.J. Call, D.L. Geiger, and C.E.
Northcott		 Acute Toxicities of Organic Chemicals to Fathead
Minnows (Pimephales promelas), Vol. 1		 Center for Lake Superior Environmental Studies,
University of Wisconsin-Superior, Superior, WI:
414 p.		 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality NOEC 246000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality 57000～418000 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, N. Ahmad, and D.D.
Vaishnav		 Aquatic Pollutant Hazard Assessments and
Development of a Hazard Prediction Technology by
Quantitative Structure-Activity
Relationships		 Second Quarterly Rep., U.S.EPA Coop.Agreement No.
CR 809234-01-0, Ctr.for Lake Superior Environ.
Stud., Univ.of Wisconsin, Superior, WI:74 p.		 1981 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth NOEC 57000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth 77400 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality NOEC 33 days 168000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:318 p.		 1992 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth NOEC 32 days 57000～105000 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, N. Ahmad, and D.D.
Vaishnav		 Aquatic Pollutant Hazard Assessments and
Development of a Hazard Prediction Technology by
Quantitative Structure-Activity
Relationships		 Second Quarterly Rep., U.S.EPA Coop.Agreement No.
CR 809234-01-0, Ctr.for Lake Superior Environ.
Stud., Univ.of Wisconsin, Superior, WI:74 p.		 1981 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality NOEC 418000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality 32 days 418000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, N. Ahmad, and D.D.
Vaishnav		 Aquatic Pollutant Hazard Assessments and
Development of a Hazard Prediction Technology by
Quantitative Structure-Activity
Relationships		 Second Quarterly Rep., U.S.EPA Coop.Agreement No.
CR 809234-01-0, Ctr.for Lake Superior Environ.
Stud., Univ.of Wisconsin, Superior, WI:74 p.		 1981 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth 33 days <56200 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:318 p.		 1992 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 537000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Broderius,S., and M. Kahl Acute Toxicity of Organic Chemical Mixtures to
the Fathead Minnow		 Aquat. Toxicol.6:307-322 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality 33 days 204000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:318 p.		 1992 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth 77400 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LOEC 33 days 248000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:318 p.		 1992 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 540000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Brooke,L.T., D.J. Call, D.L. Geiger, and C.E.
Northcott		 Acute Toxicities of Organic Chemicals to Fathead
Minnows (Pimephales promelas), Vol. 1		 Center for Lake Superior Environmental Studies,
University of Wisconsin-Superior, Superior, WI:
414 p.		 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth NOEC 57000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth NOEC 418000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality 32 days 57000～246000 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, N. Ahmad, and D.D.
Vaishnav		 Aquatic Pollutant Hazard Assessments and
Development of a Hazard Prediction Technology by
Quantitative Structure-Activity
Relationships		 Second Quarterly Rep., U.S.EPA Coop.Agreement No.
CR 809234-01-0, Ctr.for Lake Superior Environ.
Stud., Univ.of Wisconsin, Superior, WI:74 p.		 1981 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth LOEC 33 days 56200 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:318 p.		 1992 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LOEC 418000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Call,D.J., L.T. Brooke, M.L. Knuth, S.H. Poirier,
and M.D. Hoglund		 Fish Subchronic Toxicity Prediction Model for
Industrial Organic Chemicals that Produce
Narcosis		 Environ. Toxicol. Chem.4(3): 335-341 1985 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality LC50 1 days 460000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bridie,A.L., C.J.M. Wolff, and M. Winter The Acute Toxicity of Some Petrochemicals to
Goldfish		 Water Res.13(7): 623-626 1979 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 96 hours 526 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Russom, C.L., Bradbury, S.P., Broderius, S.J.,
Drummond, R.A. and Hammermeister, D.E.		 PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL
STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW
(PIMEPHALES PROMELAS)		 1997 2016/02/08
魚類 Poecilia reticulata (Guppy) Mortality LC50 96 hours 514 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Raevsky, O.A., and Dearden, J.C. Creation of predictive models of aquatic toxicity
of environmental pollutants with different
mechanisms of action on the basis of molecular
similarity and hybot descriptors.		 2004 2016/02/08
魚類 Carassius auratus (Goldfish) Mortality LC50 24 hours 458 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Lipnick, R.L., K.R. Watson, and A.K.Strausz A QSAR Study of the Acute Toxicity of Some
Industrial Organic Chemicals to Goldfish.
Narcosis, Electrophile and
Proelectrophile Mechanisms.		 1987 2016/02/08
魚類 Carassius auratus (Goldfish) Lethal EC50 24 hours 460 mg/L 9 ECETOC Aquatic Toxicity, EAT Bridie ea 79 2016/02/08
魚類 Pimephales promelas (Fathead minnow) Lethal EC50 96 hours 505 mg/L 9 ECETOC Aquatic Toxicity, EAT Veith ea 83 2016/02/08
魚類 Leuciscus idus (Orfe) Mortality LC50 96 hours 742 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Furusjö, E., Andersson, M., Rahmberg, M., Svenson,
A.		 Estimating environmentally important properties
of chemicals from the chemical structure		 2003 2016/02/08
魚類 Carassius auratus (Goldfish) Lethal EC50 24 hours 360 mg/L 9 ECETOC Aquatic Toxicity, EAT Bridie ea 79 2016/02/08