生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 108-80-5
官報公示整理番号　METI No. ： 5-1037/5-1038
物質名 test material ： イソシアヌール酸　／Isocyanuric acid
水溶解度 water solubility ： 2000mg/L (推計値 estimated)
LogKow ： 1.95 (推計値 estimated)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Pseudokirchneriella subcapitata cell number EC50 96 hours 655 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/16
藻類 Pseudokirchneriella subcapitata in vivo chlorophyll EC50 24 hours >1000 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/16
藻類 Pseudokirchneriella subcapitata in vivo chlorophyll EC50 72 hours 872 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/16
藻類 Navicula pelliculosa growth rate ErC50 96 hours >5000 mg/L Equivalent to 3780 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/22
藻類 Navicula pelliculosa biomass EbC50 72 hours 2700 mg/L equivalent to 2041 mg/L cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/21
藻類 Navicula pelliculosa growth rate ErC50 72 hours >5000 mg/L Equivalent to 3780 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/22
藻類 Navicula pelliculosa biomass EbC50 96 hours >5000 mg/L Equivalent to 3780 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/22
藻類 Pseudokirchneriella subcapitata in vivo chlorophyll EC50 48 hours >1000 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/16
藻類 Pseudokirchneriella subcapitata in vivo chlorophyll EC50 96 hours 712 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/16
藻類 Selenastrum capricornutum 生長速度 ErC50 72 hours 800 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Pseudokirchneriella subcapitata バイオマス EC50 96 hours 712 mg/L × 11 Japan チャレンジプログラム Hollister, T.A. Acute Toxicity of Cyanuric Acid (BN-78-1384330-1) to the Fresh Water Alga Selenastrum capricornutum Unpublished Study Conducted 1978 2017/01/23
藻類 Pseudokirchneriella subcapitata EC50 72 hours 950 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
藻類 Selenastrum capricornutum 生長曲線下の面積 EbC50 72 hours 620 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Pseudokirchneriella subcapitata EC50 72 hours 620 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
藻類 Selenastrum capricornutum EC50 72 hours 620 mg/L 4 OECD SIDS (HPVC) 2017/03/08
藻類 Selenastrum capricornutum 生長速度 ErC50 48 hours 780 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Navicula pelliculosa growth rate NOEC 96 hours 5000 mg/L Equivalent to 3780 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/22
藻類 Navicula pelliculosa growth rate NOEC 72 hours 1250 mg/L equivalent to 945 mg/L cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/22
藻類 Selenastrum capricornutum NOEC 72 hours 62.5 mg/L 4 OECD SIDS (HPVC) 2017/03/08
藻類 Selenastrum capricornutum 生長速度 NOEC 72 hours 125 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Selenastrum capricornutum 生長曲線下の面積 NOEC 72 hours 62.5 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Selenastrum capricornutum 生長速度 NOEC 48 hours 250 mg/L 11 Japan チャレンジプログラム 2017/01/20
藻類 Pseudokirchneriella subcapitata バイオマス NOEC 96 hours <=100 mg/L × 11 Japan チャレンジプログラム Hollister, T.A. Acute Toxicity of Cyanuric Acid (BN-78-1384330-1) to the Fresh Water Alga Selenastrum capricornutum Unpublished Study Conducted 1978 2017/01/23
藻類 Pseudokirchneriella subcapitata NOEC 72 hours 250 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
藻類 Pseudokirchneriella subcapitata NOEC 72 hours 63 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
甲殻類 Daphnia magna Physiology EC50 2 days >1000000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
甲殻類 Daphnia magna Physiology EC50 2 days >1000000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2016/03/25
甲殻類 Daphnia magna mortality LC50 48 hours >1000 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/01/21
甲殻類 Daphnia magna mortality LC50 48 hours >1000 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/13
甲殻類 Daphnia magna EC50 48 hours 1000 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
甲殻類 Daphnia magna 遊泳阻害 EC50 24 hours >1000 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna 遊泳阻害 EC50 48 hours 1000 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna EC50 48 hours >1000 mg/L 11 Japan チャレンジプログラム - 2017/01/23
甲殻類 Daphnia magna EC50 48 hours 5000～7200 × 11 Japan チャレンジプログラム Thompson, C.M. and Forbis, A.D. Acute Toxicity of Cyanuric Acid (AB-78-1384330-2a) to Daphnia magna Unpublished Study Conducted 1978 2017/01/23
甲殻類 Daphnia magna immobilisation EC50 48 hours 1000 mg/L 4 OECD SIDS (HPVC) 2017/03/08
甲殻類 Daphnia magna EC50 48 hours >1000 ppm 3 USEPA Pesticide Ecotoxicity Database C. Laird 1987 2018/03/01
甲殻類 Daphnia magna EC50 48 hours >1000 mg/L 3 USEPA Pesticide Ecotoxicity Database C. Laird 1987 2017/03/01
甲殻類 Daphnia magna 繁殖率 EC0 500 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
甲殻類 Daphnia magna reproduction EC50 21 days 2800 mg/L equivalent to 2117 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/03/13
甲殻類 Daphnia magna immobilisation EC50 21 days 2600 mg/L Equivalent to 1966 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/03/13
甲殻類 Daphnia magna mortality and reproduction LOEC 21 days 500 mg/L equivalent to 378 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/03/13
甲殻類 Daphnia magna mortality and reproduction NOEC 21 days 160 mg/L equivalent to 121 mg/l cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/03/13
甲殻類 Daphnia magna NOEC 21 days 32 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
甲殻類 Daphnia magna EC50 21 days 66 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
甲殻類 Daphnia magna 遊泳阻害 NOEC 48 hours 580 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna 繁殖阻害 LOErC 21 days 100 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna 繁殖阻害 NOErC 21 days 32 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna 繁殖阻害 ErC50 21 days 65.86 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna 繁殖阻害 ErC50 14 days 9.36 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna LC50 14 days 12.39 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna LC50 21 days 9.55 mg/L 11 Japan チャレンジプログラム 2017/01/20
甲殻類 Daphnia magna reproduction NOEC >32 mg/L 4 OECD SIDS (HPVC) 2017/03/08
甲殻類 Daphnia magna 遊泳阻害 NOEC 24 hours >1000 mg/L 11 Japan チャレンジプログラム 2017/01/20
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 2.5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality LC50 4 days 620 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 10 days 390～452 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Reimschuessel,R., C.M. Gieseker, R.A. Miller, J. Ward, J. Boehmer, N. Rummel, D.N. Heller, C. Nochetto, G.K. Hemakanthi Evaluation of the Renal Effects of Experimental Feeding of Melamine and Cyanuric Acid to Fish and Pigs Am. J. Vet. Res.69(9): 1217-1228 2008 2017/03/15
魚類 Cyprinus carpio (Carp) Mortality 2.92 days 176 mg/kg bdwt 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Loeb,H.A., and W.H. Kelly Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124 p. 1963 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Growth NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 70 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., A.J.M. Dorr, A.C. Elia, M. Scoparo, M.C. Abete, and M. Prearo Melamine-Cyanurate Complexes and Oxidative Stress Markers in Trout Kidney Following Melamine and Cyanuric Acid Long-Term Co-Exposure and Withdrawal Fish Physiol. Biochem.40:1609-1619 2014 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 70 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., A.J.M. Dorr, A.C. Elia, M. Scoparo, M.C. Abete, and M. Prearo Melamine-Cyanurate Complexes and Oxidative Stress Markers in Trout Kidney Following Melamine and Cyanuric Acid Long-Term Co-Exposure and Withdrawal Fish Physiol. Biochem.40:1609-1619 2014 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 70 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., A.J.M. Dorr, A.C. Elia, M. Scoparo, M.C. Abete, and M. Prearo Melamine-Cyanurate Complexes and Oxidative Stress Markers in Trout Kidney Following Melamine and Cyanuric Acid Long-Term Co-Exposure and Withdrawal Fish Physiol. Biochem.40:1609-1619 2014 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Growth NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Accumulation LOEL 1 days 20.6 mg/kg bdwt 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Reimschuessel,R., E. Evans, W.C. Andersen, S.B. Turnipseed, C.M. Karbiwnyk, T.D. Mayer, C. Nochetto, N.G. Rummel, and C. Residue Depletion of Melamine and Cyanuric Acid in Catfish and Rainbow Trout Following Oral Administration J. Vet. Pharmacol. Ther.33(2): 172-182 2010 2017/03/15
魚類 Lepomis macrochirus (Bluegill) Mortality NOEL 4 days 420 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2017/03/15
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Growth NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Growth NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Accumulation LOEL 1 days 20.6 mg/kg bdwt 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Reimschuessel,R., E. Evans, W.C. Andersen, S.B. Turnipseed, C.M. Karbiwnyk, T.D. Mayer, C. Nochetto, N.G. Rummel, and C. Residue Depletion of Melamine and Cyanuric Acid in Catfish and Rainbow Trout Following Oral Administration J. Vet. Pharmacol. Ther.33(2): 172-182 2010 2016/03/25
魚類 Lepomis macrochirus (Bluegill) Mortality LC50 4 days 620 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2016/03/25
魚類 Lepomis macrochirus (Bluegill) Mortality NOEL 4 days 420 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) U.S. Environmental Protection Agency Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)) Environmental Fate and Effects Division, U.S.EPA, Washington, D.C.: 1992 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 10 days 390～452 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Reimschuessel,R., C.M. Gieseker, R.A. Miller, J. Ward, J. Boehmer, N. Rummel, D.N. Heller, C. Nochetto, G.K. Hemakanthi Evaluation of the Renal Effects of Experimental Feeding of Melamine and Cyanuric Acid to Fish and Pigs Am. J. Vet. Res.69(9): 1217-1228 2008 2016/03/25
魚類 Cyprinus carpio (Carp) Mortality 2 days 75～96 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Loeb,H.A., and W.H. Kelly Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124 p. 1963 2016/03/25
魚類 Cyprinus carpio (Carp) Mortality 3 days 144～211 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Loeb,H.A., and W.H. Kelly Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124 p. 1963 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical NOEC 56 days 5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Lepomis macrochirus (Bluegill) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Cyprinus carpio (Carp) Mortality 2.92 days 176 mg/kg bdwt 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Loeb,H.A., and W.H. Kelly Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124 p. 1963 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical 56 days 2.5～10 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical 56 days 2.5～10 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical 56 days 2.5～10 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 2.5 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical LOEC 56 days 10 ppm 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Biochemical 56 days 2.5～10 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Pacini,N., M. Prearo, M.C. Abete, P. Brizio, A.J.M. Dorr, R. Reimschuessel, W. Andersen, L. Gasco, M. Righetti, and A.C. Antioxidant Responses and Renal Crystal Formation in Rainbow Trout Treated with Melamine Administered Individually or in Combination with Cyanuric Acid J. Toxicol. Environ. Health Part A76(8): 491-508 2013 2016/03/25
魚類 Lepomis macrochirus (Bluegill) mortality LC50 96 hours >1000 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/13
魚類 Menidia beryllina (Inland Silverside) mortality LC50 96 hours 8000 mg/L × 12 ECHA Information on Registered Substances 2 study report 2002 2017/03/16
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 96 hours >2100 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/13
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours >2100 mg/L × 12 ECHA Information on Registered Substances 2 study report 1978 2017/03/13
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours >100 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours >=100 mg/L 4 OECD SIDS (HPVC) 2017/03/08
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours 1080 mg/L 11 Japan チャレンジプログラム - 2017/01/23
魚類 Oryzias latipes (Japanese medaka) LC50 14 days >=100 mg/L 4 OECD SIDS (HPVC) 2017/03/08
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours >1000 mg/L × 11 Japan チャレンジプログラム Thompson, C.M. and Forbis A.D Acute Toxicity of Cyanuric Acid (AB-78-1384330-2b) to Bluegill Sunfish (Lepomis macrochirus) Unpublished Study Conducted 1978 2017/01/23
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours >2100 mg/L × 11 Japan チャレンジプログラム Thompson, C.M. and Forbis A.D Acute Toxicity of Cyanuric Acid (AB-78-1384330-2c) to Fathead Minnows (Pimephales promelas) Unpublished Study Conducted 1978 2017/01/23
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours >100 mg/L 11 Japan チャレンジプログラム 2017/01/20
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 1400 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Carassius auratus (Goldfish) LC0 24 hours >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Brachydanio rerio (Zebrafish) LC0 24 hours >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Cyprinus carpio (Carp) LC0 24 hours >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours >2100 mg/L × 11 Japan チャレンジプログラム Thompson, C.M. and Forbis A.D AcuteToxicity of Cyanuric Acid (AB-78-1384330-2d) to RainbowTrout (Salmo gairdneri) Unpublished Study Conducted 1978 2017/01/23
魚類 Brachydanio rerio (Zebrafish) LC0 20 days >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Brachydanio rerio (Zebrafish) LC0 31 days >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Oryzias latipes (Japanese medaka) LC50 7 days >100 mg/L 11 Japan チャレンジプログラム 2017/01/20
魚類 Menidia beryllina (Inland Silverside) mortality LOEC 96 hours 8000 mg/L × 12 ECHA Information on Registered Substances 2 study report 2002 2017/03/16
魚類 Oncorhynchus mykiss (Rainbow trout) growth rate LOEC 28 days >1000 mg/L Equivalent to 756 mg/L cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/21
魚類 Menidia beryllina (Inland Silverside) mortality NOEC 96 hours 4000 mg/L × 12 ECHA Information on Registered Substances 2 study report 2002 2017/03/16
魚類 Oncorhynchus mykiss (Rainbow trout) growth rate NOEC 28 days 1000 mg/L Equivalent to 756 mg/L cyanuric acid ○ 12 ECHA Information on Registered Substances 1 study report 2007 2017/01/21
魚類 Oryzias latipes (Japanese medaka) LC50 14 days >100 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
魚類 Oryzias latipes (Japanese medaka) LC50 14 days >100 mg/L 11 Japan チャレンジプログラム 2017/01/20
魚類 Oryzias latipes (Japanese medaka) NOEC 14 days >100 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成28年3月版） 2016 2016/11/08
魚類 Oryzias latipes (Japanese medaka) LOEC 14 days >100 mg/L 11 Japan チャレンジプログラム 2017/01/20
魚類 Cyprinus carpio (Carp) LC0 31 days >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Carassius auratus (Goldfish) LC0 21 days >2000 mg/L 11 Japan チャレンジプログラム PROTEAU, J.-P Recherches sur la toxicit􁪽z de l'acide cyanurique et du phosphogypse au niveau des ecosystemes aquatiques 1978 2017/01/23
魚類 Oryzias latipes (Japanese medaka) NOEC 14 days >100 mg/L 11 Japan チャレンジプログラム 2017/01/20