生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 122-99-6
官報公示整理番号　METI No. ： 9-1277/3-558/7-78
物質名 test material ： ２－フェノキシエタノール　／Ethyleneglycolmonophenyl ether
水溶解度 water solubility ： 26700mg/L (推計値 estimated)
LogKow ： 1.16 (実測値 measured)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Desmodesmus subspicatus EC50 72 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
藻類 Desmodesmus subspicatus growth rate EC50 72 hours 625 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
藻類 Desmodesmus subspicatus 72 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
藻類 Desmodesmus subspicatus biomass EC50 72 hours 443 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
藻類 Desmodesmus subspicatus 72 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
藻類 Scenedesmus subspicatus biomass EC50 72 hours >500 mg/L 4 OECD SIDS (HPVC) 2 BASF AG Labor Oekologie [Ecology Laboratory]; Algentest for monophenylglykol Unpublished study 2/1682/88 1989 2016/02/29
藻類 Desmodesmus subspicatus NOEC 72 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
藻類 Desmodesmus subspicatus growth rate EC10 72 hours 333 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
藻類 Desmodesmus subspicatus growth rate NOEC 72 hours 70 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
藻類 Desmodesmus subspicatus biomass EC10 72 hours 159 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
藻類 Scenedesmus subspicatus biomass EC10 72 hours >500 mg/L 4 OECD SIDS (HPVC) 2 BASF AG Labor Oekologie [Ecology Laboratory]; Algentest for monophenylglykol Unpublished study 2/1682/88 1989 2016/02/29
甲殻類 Daphnia magna mobility EC10 48 hours 320 mg/L × 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
甲殻類 Daphnia magna mobility EC50 48 hours 460 mg/L × 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
甲殻類 Daphnia magna EC50 48 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
甲殻類 Daphnia magna EC0 48 hours >500 mg/L × 12 ECHA Information on Registered Substances 2 study report 1989 2016/02/26
甲殻類 Daphnia magna mortality LC50 48 hours 488 mg/L 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
甲殻類 Daphnia magna mobility EC100 48 hours 750 mg/L × 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
甲殻類 Daphnia magna LC50 48 hours 488 mg/L 4 OECD SIDS (HPVC) 2 Waggy GT Glycol ethers Summary of available ecological fate and effects data Union Carbide Corporation File 1987 2016/02/29
甲殻類 Daphnia magna EC100 48 hours 750 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
甲殻類 Daphnia magna EC100 48 hours >500 mg/L 4 OECD SIDS (HPVC) 2 2016/02/29
甲殻類 Daphnia magna EC50 48 hours >500 mg/L 4 OECD SIDS (HPVC) 2 2016/02/29
甲殻類 Daphnia magna EC50 48 hours 460 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
甲殻類 Daphnia magna EC0 48 hours 500 mg/L 4 OECD SIDS (HPVC) 2 2016/02/29
甲殻類 Daphnia magna EC10 48 hours 320 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
甲殻類 Daphnia magna behaviour swimming ability of adults LC0 21 days >221 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2006 2016/02/26
甲殻類 Daphnia magna reproduction NOEC 21 days 9.43 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2006 2016/02/26
甲殻類 Daphnia magna reproduction LOEC 21 days 22.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2006 2016/02/26
甲殻類 Daphnia magna mobility NOEC 48 hours 100 mg/L × 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
甲殻類 Daphnia magna growth LOEC 21 days 110 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2006 2016/02/26
甲殻類 Daphnia magna growth NOEC 21 days 49.2 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2006 2016/02/26
甲殻類 Daphnia magna NOEC 48 hours 100 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
魚類 Oncorhynchus mykiss (Rainbow trout) Physiology 250000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fredricks,K.T., W.H. Gingerich, and D.C. Fater Comparative Cardiovascular Effects of Four Fishery Anesthetics in Spinally Transected Rainbow Trout, Oncorhynchus mykiss Comp. Biochem. Physiol. C Comp. Pharmacol.104(3): 477-483 1993 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Physiology 250000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fredricks,K.T., W.H. Gingerich, and D.C. Fater Comparative Cardiovascular Effects of Four Fishery Anesthetics in Spinally Transected Rainbow Trout, Oncorhynchus mykiss Comp. Biochem. Physiol. C Comp. Pharmacol.104(3): 477-483 1993 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Behavior 0.03 hours 200000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Gilderhus,P.A., and L.L. Marking Comparative Efficacy of 16 Anesthetic Chemicals on Rainbow Trout N. Am. J. Fish. Manag.7(2): 288-292 1987 2016/03/25
魚類 Cyprinus carpio (Carp) Physiology 0.1～0.6 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Josa,A., E. Espinosa, J.I. Cruz, L. Gil, M.V. Falceto, and R. Lozano Use of 2-Phenoxyethanol as an Anaesthetic Agent in Goldfish (Cyprinus carpio) Vet. Rec.131(20): 468- 1992 2016/03/25
魚類 Lepomis macrochirus (Bluegill) Physiology 4 days 501000～651000 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Carlson,R.W. Ventilatory Patterns of Bluegill (Lepomis macrochirus) Exposed to Organic Chemicals with Different Mechanisms of Toxic Action Comp. Biochem. Physiol. C Comp. Pharmacol.95(2): 181-196 1990 2016/03/25
魚類 Cyprinus carpio (Carp) Physiology 400000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Yamamitsu,S., and Y. Itazawa Effects of an Anesthetic 2-Phenoxyethanol on the Heart Rate, ECG and Respiration in Carp Nippon Suisan Gakkaishi54(10): 1737-1746 1988 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Behavior 0.04 hours 300000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Gilderhus,P.A., and L.L. Marking Comparative Efficacy of 16 Anesthetic Chemicals on Rainbow Trout N. Am. J. Fish. Manag.7(2): 288-292 1987 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Accumulation 200000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Imamura-Kojima,H., F. Takashima, and T. Yoshida Absorption, Distribution and Excretion of 2-Phenoxyetanol in Rainbow Trout Nippon Suisan Gakkaishi53(8): 1339-1342 1987 2016/03/25
魚類 Danio rerio (Zebrafish) No Group Code 5 days 80 μM 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Padilla,S., D. Corum, B. Padnos, D.L. Hunter, A. Beam, K.A. Houck, N. Sipes, N. Kleinstreuer, T. Knudsen, D.J. Dix, and Zebrafish Developmental Screening of the ToxCast Phase I Chemical Library Reprod. Toxicol.33(2): 174-187 2012 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 344000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Brooke,L.T., D.J. Call, D.L. Geiger, and C.E. Northcott Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 1 Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI:414 p. 1984 2016/03/25
魚類 Lepomis macrochirus (Bluegill) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Reproduction 0.25 hours 0.1 % v/v 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Billard,R. Effect of Some Fish Anesthetics on Gamete Survival During Artificial Insemination of Rainbow Trout Prog. Fish-Cult.43(2): 72-73 1981 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Reproduction 0.25 hours 0.05 % v/v 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Billard,R. Effect of Some Fish Anesthetics on Gamete Survival During Artificial Insemination of Rainbow Trout Prog. Fish-Cult.43(2): 72-73 1981 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Reproduction 0.33 hours 0.01～0.5 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Billard,R. Effect of Some Fish Anesthetics on Gamete Survival During Artificial Insemination of Rainbow Trout Prog. Fish-Cult.43(2): 72-73 1981 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Physiology 250000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Fredricks,K.T., W.H. Gingerich, and D.C. Fater Comparative Cardiovascular Effects of Four Fishery Anesthetics in Spinally Transected Rainbow Trout, Oncorhynchus mykiss Comp. Biochem. Physiol. C Comp. Pharmacol.104(3): 477-483 1993 2016/03/25
魚類 Danio rerio (Zebrafish) mortality LC50 96 hours 312.1～349 × 12 ECHA Information on Registered Substances 2 Mácová, S., Dolezelova, P., Pistekova, V., Svobodova, Z., Bedanova, I. & Voslarova, E. Comparison of acute toxicity of 2-phenoxyethanol and clove oil to juvenile and embryonic stages of Danio rerio Neuroendocrinology Letters 2008 2016/02/26
魚類 Leuciscus idus (Orfe) mortality LC50 96 hours >220～<460 × 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours 366 mg/L 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
魚類 Leuciscus idus (Orfe) mortality LC0 96 hours 220 mg/L × 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
魚類 Danio rerio (Zebrafish) mortality LC100 96 hours 185 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
魚類 Leuciscus idus (Orfe) mortality LC100 96 hours 460 mg/L × 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
魚類 Lepomis macrochirus (Bluegill) mortality LC50 24 hours >5 mg/L × 12 ECHA Information on Registered Substances 4 study report 1957 2016/02/26
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 24 hours >5 mg/L × 12 ECHA Information on Registered Substances 4 study report 1957 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LC100 96 hours 560 mg/L 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours 478 mg/L 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
魚類 Danio rerio (Zebrafish) mortality LC0 96 hours 128 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours 344 mg/L 12 ECHA Information on Registered Substances 2 publication 1984 2016/02/26
魚類 Danio rerio (Zebrafish) mortality LC50 96 hours 154 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1994 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LC10 96 hours 236 mg/L 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
魚類 Pimephales promelas (Fathead minnow) Lethal EC50 96 hours 344 mg/L 9 ECETOC Aquatic Toxicity, EAT Veith ea 83 2016/02/08
魚類 Pimephales promelas (Fathead minnow) LC10 96 hours 180 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 366 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC100 96 hours 560 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29
魚類 Poecilia reticulata (Guppy) Mortality LC50 96 hours 347 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Raevsky, O.A., and Dearden, J.C. Creation of predictive models of aquatic toxicity of environmental pollutants with different mechanisms of action on the basis of molecular similarity and hybot descriptors. 2004 2016/02/08
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 96 hours 347 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Russom, C.L., Bradbury, S.P., Broderius, S.J., Drummond, R.A. and Hammermeister, D.E. PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS) 1997 2016/02/08
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 344 mg/L 4 OECD SIDS (HPVC) 4 Brooke, L.T. et al Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas) 1984 2016/02/29
魚類 Lepomis macrochirus (Bluegill) LC0 96 hours 370 mg/L 4 OECD SIDS (HPVC) 4 Carlson, R.W Comp Biochem. Physiol 1990 2016/02/29
魚類 Leuciscus idus (Orfe) LC50 96 hours 220～460 × 4 OECD SIDS (HPVC) 4 BASF AG Abteilung Toxikologie [Toxicology Division] unveroeffentlichte Untersuchung [unpublished study] (87/407) 1988 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 478 mg/L 4 OECD SIDS (HPVC) 4 TSCAT OTS0514003, Doc I.D. 86-880000113, 8D 1987 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 344 mg/L 4 OECD SIDS (HPVC) 1 Veith, G.D. et al.: ASTM Spec. Tech. Publ Iss. Aquat. Toxicol. Hazard Assess 1973 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 478 mg/L 4 OECD SIDS (HPVC) 4 Waggy GT Glycol ethers: Summary of available ecological fate and effects data Union Carbide Corporation File 1987 2016/02/29
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 366 mg/L 4 OECD SIDS (HPVC) 4 TSCAT OTS0206699, Doc I.D. 878214908 1976 2016/02/29
魚類 Danio rerio (Zebrafish) mortality LC50 6 days 461.5～521.6 × 12 ECHA Information on Registered Substances 2 Mácová, S., Dolezelova, P., Pistekova, V., Svobodova, Z., Bedanova, I. & Voslarova, E. Comparison of acute toxicity of 2-phenoxyethanol and clove oil to juvenile and embryonic stages of Danio rerio Neuroendocrinology Letters 2008 2016/02/26
魚類 Pimephales promelas (Fathead minnow) sublethal effects NOEC 34 days 105.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 34 days 23 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 96 hours 100 mg/L 12 ECHA Information on Registered Substances 4 study report 1976 2016/02/26
魚類 Pimephales promelas (Fathead minnow) length LOEC 34 days 105.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LOEC 34 days 50 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Lepomis macrochirus (Bluegill) effect on breathing of fish LOEC 96 hours 370 mg/L 12 ECHA Information on Registered Substances 4 Carlson, R.W. Comparative Biochemistry and Physiology, Part C Toxicology and Pharmacology 1990 2016/02/26
魚類 Lepomis macrochirus (Bluegill) mortality NOEC 24 hours 5 mg/L × 12 ECHA Information on Registered Substances 4 study report 1957 2016/02/26
魚類 Pimephales promelas (Fathead minnow) weight NOEC 34 days 51.3 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) time to hatch NOEC 8 days >220 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Oncorhynchus mykiss (Rainbow trout) mortality NOEC 24 hours 5 mg/L × 12 ECHA Information on Registered Substances 4 study report 1957 2016/02/26
魚類 Pimephales promelas (Fathead minnow) weight LOEC 34 days 105.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Leuciscus idus (Orfe) mortality NOEC 96 hours 100 mg/L × 12 ECHA Information on Registered Substances 2 study report 1988 2016/02/26
魚類 Pimephales promelas (Fathead minnow) time to swim up NOEC 8 days >220 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) sublethal effects LOEC 34 days 215 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) length NOEC 34 days 51.3 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality LOEC 34 days 51.3 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 34 days 24 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2005 2016/02/26
魚類 Pimephales promelas (Fathead minnow) NOEC 96 hours 100 mg/L 4 OECD SIDS (HPVC) 4 TSCAT OTS0206699, Doc I.D. 878214908 1976 2016/02/29
魚類 Leuciscus idus (Orfe) NOEC 96 hours 100 mg/L × 4 OECD SIDS (HPVC) 4 BASF AG Abteilung Toxikologie [Toxicology Division] unveroeffentlichte Untersuchung [unpublished study] (87/407) 1988 2016/02/29
魚類 Pimephales promelas (Fathead minnow) NOEC 96 hours 100 mg/L 4 OECD SIDS (HPVC) 4 Batchelder TL Analysis of Dowanol EPh in the aquatic environment Dow Chemical Research Report ES-80 1976 2016/02/29