【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。
| 生物種 | 学名 | 影響内容 | エンドポイント | 暴露期間(値) | 暴露期間(単位) | 毒性値 | 毒性値(単位) | 毒性値(単位)種別 | 試験中の 被験物質 濃度測定 あり：○ なし：× |
情報源 | 情報源による 信頼性評価** |
著者 | タイトル | 記載誌 | 発行年 | 情報更新日 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| subject type | scientific name | effect | endpoint | exposure duration value |
exposure duration unit |
toxicity value | toxicity unit | toxicity unit type | Read-across* | QSAR | GLP | measurement of the test material |
original work type | original work reliability rank |
author | title | referenced journal | publication year | Information update date |
| 藻類 | Pseudokirchneriella subcapitata | growth rate | EC50 | 72 | hours | >0.7 | mg/L | 12 ECHA Information on Registered Substances | 2 | study report | 2012 | 2017/01/30 | |||||||
| 藻類 | Pseudokirchneriella subcapitata | growth rate | EC50 | 72 | hours | >0.854 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 藻類 | Pseudokirchneriella subcapitata | biomass | EC50 | 72 | hours | 0.723 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 藻類 | Pseudokirchneriella subcapitata | biomass | EC50 | 72 | hours | 0.723 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/12 | ||||||||||
| 藻類 | Pseudokirchneriella subcapitata | growth rate | EC50 | 72 | hours | 0.854 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/12 | ||||||||||
| 藻類 | Pseudokirchneriella subcapitata | EbC50 | 72 | hours | 0.723 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Van Dijk A. | Acute toxicity of HHCB to Pseudokirchneriella subcapitata. | RCC Umweltchemie AG Project 380632. Report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | |||||
| 藻類 | Pseudokirchneriella subcapitata | ErC50 | 72 | hours | >0.854 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Van Dijk A. | Acute toxicity of HHCB to Pseudokirchneriella subcapitata. | RCC Umweltchemie AG Project 380632. Report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | |||||
| 藻類 | Pseudokirchneriella subcapitata | growth rate | NOEC | 72 | hours | 0.23 | mg/L | 12 ECHA Information on Registered Substances | 2 | study report | 2012 | 2017/01/30 | |||||||
| 藻類 | Pseudokirchneriella subcapitata | growth rate | NOEC | 72 | hours | 0.201 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 藻類 | Pseudokirchneriella subcapitata | growth rate | NOEC | 72 | hours | 0.201 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/13 | ||||||||||
| 藻類 | Pseudokirchneriella subcapitata | biomass production, growth rate | LOEC | 72 | hours | 0.466 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Van Dijk A. | Acute toxicity of HHCB to Pseudokirchneriella subcapitata. | RCC Umweltchemie AG Project 380632. Report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 藻類 | Pseudokirchneriella subcapitata | biomass production, growth rate | NOEC | 72 | hours | 0.201 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Van Dijk A. | Acute toxicity of HHCB to Pseudokirchneriella subcapitata. | RCC Umweltchemie AG Project 380632. Report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 甲殻類 | Daphnia magna | mobility | EC50 | 48 | hours | 0.3 | mg/L | 12 ECHA Information on Registered Substances | 2 | study report | 2012 | 2017/01/30 | |||||||
| 甲殻類 | Daphnia magna | mobility | EC50 | 72 | hours | 885 | μg/L | ○ | 12 ECHA Information on Registered Substances | 2 | study report | 1996 | 2017/03/03 | ||||||
| 甲殻類 | Daphnia magna | EC50 | 48 | hours | >0.9 | mg/L | ○ | 12 ECHA Information on Registered Substances | 2 | study report | 1996 | 2017/03/03 | |||||||
| 甲殻類 | Daphnia magna | immobility | EC50 | 72 | hours | 0.88 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/12 | ||||||||||
| 甲殻類 | Daphnia magna | mortality | IC50 | 21 | days | 293 | μg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 甲殻類 | Daphnia magna | reproduction | EC50 | 21 | days | 282 | μg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 甲殻類 | Daphnia magna | immobilisation | LOEC | 21 | days | 205 | μg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 甲殻類 | Daphnia magna | reproduction | NOEC | 21 | days | 111 | μg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 甲殻類 | Daphnia magna | reproduction | NOEC | 21 | days | 0.111 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/13 | ||||||||||
| 甲殻類 | Daphnia magna | reproduction | LOEC | 21 | days | 0.205 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | Influence of HHCB on the reproduction of Daphnia magna. | RCC Umweltchemie AG Project 380687. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | ||||
| 甲殻類 | Daphnia magna | reproduction | NOEC | 21 | days | 0.111 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | Influence of HHCB on the reproduction of Daphnia magna. | RCC Umweltchemie AG Project 380687. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | ||||
| 甲殻類 | Daphnia magna | reproduction | EC50 | 21 | days | 0.282 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | Influence of HHCB on the reproduction of Daphnia magna. | RCC Umweltchemie AG Project 380687. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | ||||
| 甲殻類 | Daphnia magna | IC50 | 21 | days | 0.293 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | Influence of HHCB on the reproduction of Daphnia magna. | RCC Umweltchemie AG Project 380687. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | |||||
| 魚類 | Danio rerio (Zebrafish) | Cellular Effects: | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Growth | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Growth | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Mortality | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Behavior | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Physiology | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Physiology | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Mortality | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2017/03/15 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Physiology | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Mortality | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Growth | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Growth | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Behavior | NOEC | 1 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Physiology | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Mortality | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Danio rerio (Zebrafish) | Cellular Effects | NOEC | 2 | days | 1000 | μg/L | 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) | Carlsson,G., and L. Norrgren | Synthetic Musk Toxicity to Early Life Stages of Zebrafish (Danio rerio) | Arch. Environ. Contam. Toxicol.46(1): 102-105 | 2004 | 2016/03/25 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | mortality | LC50 | 4 | days | 1.36 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Oryzias latipes (Japanese medaka) | mortality | LC50 | 96 | hours | 0.95 | mg/L | 12 ECHA Information on Registered Substances | 2 | Yamauchi, R., Ishibashi, H., Hirano, M., Mori, T., Kim, J. & Arizono, K. | Effects of synthetic polycyclic musks on estrogen receptor, vitellogenin, pregnane X receptor, and cytochrome P450 3A gene expression in the livers of male medaka (Oryzias latipes) | Aquatic Toxicology | 2008 | 2017/01/30 | |||||
| 魚類 | Lepomis macrochirus (Bluegill) | mortality | LC50 | 21 | days | 0.452 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | mortality | LC50 | 96 | hours | 1.36 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/12 | ||||||||||
| 魚類 | Brachydanio rerio (Zebrafish) | hatching | EC50 | 96 | hours | 0.39 | mg/L | × | 7 EU Risk Assessment Report (EUリスク評価書） | DQ4 | Dietrich DR and Chou Y-J. | Ecotoxicology of musks. | In: American Chemical Society Symposium Series 791, Pharmaceutical and Personal Care Products in the Environment: Scientific and Regulatory Issues., ed.s C.G. Daughton and T. Jones-Lepp. American Chemical Society Washington DC. | 2001 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | growth rate | NOEC | 36 | days | 0.068 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | behaviour | LOEC | 21 | days | 0.182 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | survival | LOEC | 36 | days | 0.14 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | mortality | LC50 | 21 | days | 0.452 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | survival | NOEC | 36 | days | 0.068 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | growth rate | NOEC | 21 | days | 0.182 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | growth rate | LOEC | 36 | days | 0.14 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | clinical signs | NOEC | 21 | days | 0.093 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | behaviour | LOEC | 21 | days | 0.182 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | growth rate | NOEC | 21 | days | 0.182 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Lepomis macrochirus (Bluegill) | clinical signs | NOEC | 21 | days | 0.093 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1996 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | development | NOEC | 36 | days | 0.068 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | mortality | LC50 | 36 | days | >0.14 | mg/L | based on number of larvae released on exposure day 4 | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | |||||
| 魚類 | Pimephales promelas (Fathead minnow) | development | LOEC | 36 | days | 0.14 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | number hatched | LOEC | 36 | days | >0.14 | mg/L | ○ | 12 ECHA Information on Registered Substances | 1 | study report | 1997 | 2017/01/30 | ||||||
| 魚類 | Pimephales promelas (Fathead minnow) | survival, growth, development | NOEC | 32 | days | 0.068 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/13 | ||||||||||
| 魚類 | Lepomis macrochirus (Bluegill) | respiration, equilibrium | NOEC | 21 | days | 0.093 | mg/L | 4 OECD SIDS (HPVC) | 2017/03/13 | ||||||||||
| 魚類 | Pimephales promelas (Fathead minnow) | surv. | LOEC | 36 | days | 0.14 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | LC50 | 36 | days | >0.14 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | |||||
| 魚類 | Pimephales promelas (Fathead minnow) | growth | NOEC | 36 | days | 0.068 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Lepomis macrochirus (Bluegill) | LC50 | 21 | days | 0.452 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | HHCB: 21-Day prolonged toxicity study in the bluegill sunfish under flow-through conditions. | RCC Umweltchemie AG Project 380711. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | |||||
| 魚類 | Lepomis macrochirus (Bluegill) | LOEC | 21 | days | 0.182 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | HHCB: 21-Day prolonged toxicity study in the bluegill sunfish under flow-through conditions. | RCC Umweltchemie AG Project 380711. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | |||||
| 魚類 | Lepomis macrochirus (Bluegill) | clinical signs | NOEC | 21 | days | 0.093 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | HHCB: 21-Day prolonged toxicity study in the bluegill sunfish under flow-through conditions. | RCC Umweltchemie AG Project 380711. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | hatch | LOEC | 36 | days | >0.14 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | surv. | NOEC | 36 | days | 0.068 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Brachydanio rerio (Zebrafish) | development | NOEC | 3 | days | 0.4 | mg/L | × | 7 EU Risk Assessment Report (EUリスク評価書） | DQ4 | Schreurs R., Van der Burg B, Seinen W. | Selective (anti-)estrogenic activity of polycyclic musks. | 40th Annual Meeting of the Society of Toxicology, San Francisco, USA. Toxicol. Sci | 2001 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | develop. | LOEC | 36 | days | 0.14 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | growth | LOEC | 36 | days | 0.14 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 | ||||
| 魚類 | Brachydanio rerio (Zebrafish) | larval devel. | NOEC | 48 | hours | >1 | mg/L | × | 7 EU Risk Assessment Report (EUリスク評価書） | DQ2 | Carlson G, Norrgren L. | Synthetic musk toxicity on zebrafish (Danio rerio) early life stages. | Arch. Envron. Contam. Toxicol. | 2004 | 2017/02/09 | ||||
| 魚類 | Brachydanio rerio (Zebrafish) | heart rate | NOEC | 48 | hours | >=1 | mg/L | × | 7 EU Risk Assessment Report (EUリスク評価書） | DQ2 | Carlson G, Norrgren L. | Synthetic musk toxicity on zebrafish (Danio rerio) early life stages. | Arch. Envron. Contam. Toxicol. | 2004 | 2017/02/09 | ||||
| 魚類 | Lepomis macrochirus (Bluegill) | growth | NOEC | 21 | days | 0.182 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Wüthrich V. | HHCB: 21-Day prolonged toxicity study in the bluegill sunfish under flow-through conditions. | RCC Umweltchemie AG Project 380711. Report to Research Institute for Fragrance materials RIFM. | 1996 | 2017/02/09 | ||||
| 魚類 | Pimephales promelas (Fathead minnow) | develop. | NOEC | 36 | days | 0.068 | mg/L | ○ | 7 EU Risk Assessment Report (EUリスク評価書） | DQ1 | Croudace CP, Caunter JE, Johnson PA, Wallace SJ. | HHCB: Chronic toxicity to fathead minnow (Pimephales promelas) embryos and larvae. | Zeneca Project Report BL5934/B. Unpublished report to Research Institute for Fragrance materials RIFM. | 1997 | 2017/02/09 |