生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 139-33-3
官報公示整理番号　METI No. ： 2-1265
物質名 test material ： エチレンジアミン四酢酸二ナトリウム　／Disodium dihydrogen E.D.T.A.
水溶解度 water solubility ： 1000000mg/L (推計値 estimated)
LogKow ： -11.7 (推計値 estimated)
備考 remarks ：
Excelファイルダウンロード

【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Desmodesmus subspicatus growth rate EC90 72 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Scenedesmus sp. Population 500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Staub,R.J., J.W. Appling, and J. Haas Effects of Industrial Effluents on Primary Phytoplankton Indicators Res.Rep.No.26, Tennessee Water Resour.Res.Ctr., April 1973, Knoxville, TN:19 p. 1973 2016/03/25
藻類 Pseudokirchneriella subcapitata Population 30～300 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Chen,C.Y., and K.C. Lin Optimization and Performance Evaluation of the Continuous Algal Toxicity Test Environ. Toxicol. Chem.16(7): 1337-1344 1997 2016/03/25
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >60.6 mg/L meas. (arithm. mean), H4EDTA ○ 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Desmodesmus subspicatus growth rate EC50 72 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >1000 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >60 mg/L meas. (arithm. mean), H4EDTA 12 ECHA Information on Registered Substances 1 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 2021/10/25
藻類 Scenedesmus quadricauda NOEC 24 days 200 mg/L 4 OECD SIDS (HPVC) 2021/08/13
藻類 Scenedesmus subspicatus EC10 72 hours >100 mg/L 4 OECD SIDS (HPVC) 2021/08/13
藻類 Desmodesmus subspicatus growth rate NOEC 72 hours >=100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 48.4 mg/L meas. (arithm. mean), H4EDTA ○ 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 48.4 mg/L meas. (arithm. mean), H4EDTA 12 ECHA Information on Registered Substances 1 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate EC10 72 hours 307.63 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours >=100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Desmodesmus subspicatus growth rate LOEC 72 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 79.4 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 2021/10/25
藻類 Desmodesmus subspicatus growth rate EC10 72 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
甲殻類 Daphnia magna mobility EC100 48 hours 180 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 other: Scientific and Technical Research Report 2021/10/25
甲殻類 Daphnia magna mobility EC0 48 hours 100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
甲殻類 Daphnia magna mobility EC50 48 hours >114 mg/L meas. (geom. mean), act. ingr. 12 ECHA Information on Registered Substances 1 study report 2021/10/25
甲殻類 Daphnia magna mobility EC50 48 hours 140 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 Ewell WS, et al. Simultaneous evaluation of the acute effects of chemicals on seven aquatic species Environ Toxicol Chem 5: 831 - 840 2021/10/25
甲殻類 Daphnia magna NOEC 21 days 22 mg/L 4 OECD SIDS (HPVC) 2021/08/13
甲殻類 Daphnia magna NOEC 21 days 25 mg/L 4 OECD SIDS (HPVC) 2021/10/18
甲殻類 Daphnia magna reproduction NOEC 21 days 25 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
甲殻類 Daphnia magna reproduction LOEC 21 days 50 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
魚類 Carassius auratus (Goldfish) Mortality 2 days 0.2 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 1 days 860000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Jancovic,M., and H. Mann Untersuchungen Uber Die Akute Toxische Wirkung Von Nitrilotriessigsaure (NTA) Arch. Fischereiwiss.20(2-3): 178-181 1969 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 1 days 0.2 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 2 days 0.2 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Lepomis macrochirus (Bluegill) No Group Code 1 days 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 1 days 0.2 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 1 days 0.2 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 2 days 0.1 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Carassius auratus (Goldfish) Mortality 1 days 0.4 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Cascella,P.J., and P.D. Kindelspire Effect of Edetate Disodium on Goldfish Membrane J. Pharm. Sci.69(8): 972-974 1980 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC100 24 hours 860 mg/L 4 OECD SIDS (HPVC) 2021/08/13
魚類 Poecilia reticulata (Guppy) Mortality LC50 96 hours 320 mg/L 4 OECD SIDS (HPVC) 2021/08/13
魚類 Oncorhynchus mykiss Mortality/Mortality NR-LETH 24 hours 860000 μg/L × 16 ECOTOX Jancovic,M., and H. Mann Untersuchungen Uber Die Akute Toxische Wirkung Von Nitrilotriessigsaure (NTA) Arch. Fischereiwiss.20(2-3) 1969 2021/08/11
魚類 Lepomis macrochirus mortality LC50 96 hours 2340 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Lepomis macrochirus mortality LC100 96 hours 4200 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours >116 mg/L meas. (arithm. mean), act. ingr. ○ 12 ECHA Information on Registered Substances 2 Kramer KJM, Jak RG, Van Hattum B, Hooftman RN, Zwolsman JJG Copper toxicity in relation to surface water-dissolved organic matter: biological effects to Daphnia magna Environmental Toxicology and Chemistry 23(12):2971-2980 2021/10/25
魚類 Lepomis macrochirus mortality LC50 96 hours 275 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Oncorhynchus mykiss mortality LC100 96 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 other: Scientific and Technical Research Report 2021/10/25
魚類 Oncorhynchus mykiss mortality LC50 96 hours >116 mg/L meas. (arithm. mean), act. ingr. 12 ECHA Information on Registered Substances 1 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours 2340 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Markich SJ, Batley GE, Stauber JL, Rogers NJ, Apte SC, Hyne RV, Bowles KC, Wilde KL, Creighton NM Hardness corrections for copper are inappropriate for protecting sensitive freshwater biota Chemosphere 60:1-8 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours 401.7 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Johnson BM, Chao MM, Tedrow OR, McQueen AD, Rodgers JH Jr. Responses of Lepomis macrochirus, Pimephales promelas, Hyalella azteca, Ceriodaphnia dubia, and Daphnia magna to exposures of Algimycin PWF and copper sulfate pentahydrate Journal of Aquatic Plant Management 46:176-183 2021/10/25
魚類 Lepomis macrochirus mortality LC100 96 hours 390 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Lepomis macrochirus mortality LC50 96 hours 401.7 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours >100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Villavicencio G, Urrestarazu P, Carvajal C, De Schamphelaere KAC, Janssen CJ, Torres JC, Rodriguez PH Biotic Ligand Model prediction of copper toxicity to daphnids in a range of natural waters in Chile Environmental Toxicology and Chemistry 24(5):1287-1299 2021/10/25
魚類 Lepomis macrochirus mortality LC100 96 hours 2246 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours 390 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Hyne RV, Pablo F, Julli M, Markich SJ Influence of water chemistry on the acute toxicity of copper and zinc to the cladoceran Ceriodaphnia cf dubia Environmental Toxicology and Chemistry 24(7);1667-1675 2021/10/25
魚類 Oncorhynchus mykiss mortality NOEC 96 hours 100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours 240 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
魚類 Lepomis macrochirus mortality LC50 96 hours 938 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours 436 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Johnson BM, Chao MM, Tedrow OR, McQueen AD, Rodgers JH Jr. Responses of Lepomis macrochirus, Pimephales promelas, Hyalella azteca, Ceriodaphnia dubia, and Daphnia magna to exposures of Algimycin PWF and copper sulfate pentahydrate Journal of Aquatic Plant Management 46:176-183 2021/10/25
魚類 Pimephales promelas mortality NOEC 96 hours 100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Villavicencio G, Urrestarazu P, Carvajal C, De Schamphelaere KAC, Janssen CJ, Torres JC, Rodriguez PH Biotic Ligand Model prediction of copper toxicity to daphnids in a range of natural waters in Chile Environmental Toxicology and Chemistry 24(5):1287-1299 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours >100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours >100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Villavicencio G, Urrestarazu P, Carvajal C, De Schamphelaere KAC, Janssen CJ, Torres JC, Rodriguez PH Biotic Ligand Model prediction of copper toxicity to daphnids in a range of natural waters in Chile Environmental Toxicology and Chemistry 24(5):1287-1299 2021/10/25
魚類 Oncorhynchus mykiss mortality LC50 96 hours >100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 Batchelder TL et al. Acute Fish Toxicity of the Versene Family of Chelating Agents Bull Environ Contam Toxicol 24: 543-549 2021/10/25
魚類 Oncorhynchus mykiss mortality LC0 96 hours 100 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 other: Scientific and Technical Research Report 2021/10/25
魚類 Lepomis macrochirus mortality LC100 96 hours 436 mg/L nominal, act. ingr. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Lepomis macrochirus mortality LC50 96 hours 159 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours 159 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Kramer KJM, Jak RG, Van Hattum B, Hooftman RN, Zwolsman JJG Copper toxicity in relation to surface water-dissolved organic matter: biological effects to Daphnia magna Environmental Toxicology and Chemistry 23(12):2971-2980 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours 4200 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Markich SJ, Batley GE, Stauber JL, Rogers NJ, Apte SC, Hyne RV, Bowles KC, Wilde KL, Creighton NM Hardness corrections for copper are inappropriate for protecting sensitive freshwater biota Chemosphere 60:1-8 2021/10/25
魚類 Pimephales promelas mortality LC100 96 hours 2246 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Long KE, Van Genderen EJ, Klaine SJ The effects of low hardness and pH on copper toxicity to Daphnia magna Environmental Toxicology and Chemistry 23(1):72-75 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours 938 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Villavicencio G, Urrestarazu P, Carvajal C, De Schamphelaere KAC, Janssen CJ, Torres JC, Rodriguez PH Biotic Ligand Model prediction of copper toxicity to daphnids in a range of natural waters in Chile Environmental Toxicology and Chemistry 24(5):1287-1299 2021/10/25
魚類 Pimephales promelas mortality LC0 96 hours 100 mg/L nominal, test mat. ○ 12 ECHA Information on Registered Substances 2 Villavicencio G, Urrestarazu P, Carvajal C, De Schamphelaere KAC, Janssen CJ, Torres JC, Rodriguez PH Biotic Ligand Model prediction of copper toxicity to daphnids in a range of natural waters in Chile Environmental Toxicology and Chemistry 24(5):1287-1299 2021/10/25
魚類 Pimephales promelas mortality LC50 96 hours 275 mg/L nominal, act. ingr. ○ 12 ECHA Information on Registered Substances 2 Long KE, Van Genderen EJ, Klaine SJ The effects of low hardness and pH on copper toxicity to Daphnia magna Environmental Toxicology and Chemistry 23(1):72-75 2021/10/25
魚類 Lepomis macrochirus mortality LC100 96 hours 240 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 2 study report 2021/10/25
魚類 Danio rerio (Zebrafish) NOEC 35 days >26.8 mg/L 4 OECD SIDS (HPVC) 2021/08/13
魚類 Danio rerio all considered endpoints NOEC 35 days >=35.1 mg/L nominal, test mat. 12 ECHA Information on Registered Substances 1 study report 2021/10/25