生態影響に係る有害性情報

CAS登録番号 CAS RN ® ： 4098-71-9
官報公示整理番号　METI No. ： 3-2492
物質名 test material ：３－イソシアナトメチル－３，５，５－トリメチルシクロヘキシル＝イソシアナート　／3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate
水溶解度 water solubility ： 2.928mg/L (推計値 estimated)
LogKow ： 4.75 (推計値 estimated)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし

生物種	学名	影響内容	エンドポイント	暴露期間(値)	暴露期間(単位)	毒性値	毒性値(単位)	毒性値(単位)種別				試験中の被験物質濃度測定あり：○ なし：×	情報源	情報源による信頼性評価**	著者	タイトル	記載誌	発行年	情報更新日
subject type	scientific name	effect	endpoint	exposure duration value	exposure duration unit	toxicity value	toxicity unit	toxicity unit type	Read-across*	QSAR	GLP	measurement of the test material	original work type	original work reliability rank	author	title	referenced journal	publication year	Information update date
藻類	Scenedesmus subspicatus		EC50	72	hours	118.7	mg/L				×		11 Japan チャレンジプログラム		Huels Untersuchung				2017/01/30
藻類	Scenedesmus subspicatus	増殖阻害	EC50	72	hours	118.7	mg/L						18 既存化学物質安全性(ハザード)評価シート		EU		IUCLID(International Uniform Chemical Information Data Base)Data Set	2000	2016/02/26
藻類	Desmodesmus subspicatus	growth rate	EC50	72	hours	119	mg/L				×		12 ECHA Information on Registered Substances	4	study report			1988	2017/02/27
藻類	Desmodesmus subspicatus	growth rate	EC50	72	hours	119	mg/L				×		4 OECD SIDS (HPVC)	4	Hüls AG	Algenwachstumshemmtest nach UBA (Stand Feb. 1984) - Scenedesmus subspicatus, Produkt Isophorondiisocyanat.	Report No. AW 145/1+2 (unpublished, 1 p).	1988	2017/02/21
藻類	Desmodesmus subspicatus	biomass	EC50	72	hours	>70	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	Growth：生長（速度法）	EC50	3	days	>70000	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
藻類	Desmodesmus subspicatus	growth rate	EC50	72	hours	>70	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	growth rate	EC50	72	hours	>70	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
藻類	Scenedesmus subspicatus		EC10	72	hours	18.8	mg/L				×		11 Japan チャレンジプログラム		Huels Untersuchung				2017/01/30
藻類	Desmodesmus subspicatus	growth rate	NOEC	72	hours	4.4	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
藻類	Desmodesmus subspicatus	growth rate	LOEC	72	hours	8.8	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
藻類	Desmodesmus subspicatus	growth rate	EC10	72	hours	19	mg/L				×		12 ECHA Information on Registered Substances	4	study report			1988	2017/02/27
藻類	Desmodesmus subspicatus	biomass	NOEC	72	hours	>=70	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	growth rate	NOEC	72	hours	4.4	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	growth rate	LOEC	72	hours	8.8	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	growth rate	EC10	72	hours	19	mg/L				×		4 OECD SIDS (HPVC)	4	Hüls AG	Algenwachstumshemmtest nach UBA (Stand Feb. 1984) - Scenedesmus subspicatus, Produkt Isophorondiisocyanat.	Report No. AW 145/1+2 (unpublished, 1 p).	1988	2017/02/21
藻類	Desmodesmus subspicatus	biomass	NOEC	72	hours	>70	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
藻類	Desmodesmus subspicatus	Growth：生長（速度法）	NOEC	3	days	4400	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
甲殻類	Daphnia magna	遊泳阻害	EC50	24	hours	83.7	mg/L						18 既存化学物質安全性(ハザード)評価シート		EU		IUCLID(International Uniform Chemical Information Data Base)Data Set	2000	2016/02/26
甲殻類	Daphnia magna	mobility	EC50	48	hours	35	mg/L				○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
甲殻類	Daphnia magna	mobility	EC50	24	hours	84	mg/L				×		12 ECHA Information on Registered Substances	4	study report			1988	2017/02/27
甲殻類	Daphnia magna	mobility	EC0	48	hours	19	mg/L				○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
甲殻類	Daphnia magna	immobilization	EC50	48	hours	>65	mg/L				○		4 OECD SIDS (HPVC)	2	Hüls AG	Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna.	Report No. DK-654 (unpublished).	1995	2017/02/21
甲殻類	Daphnia magna	immobilization	EC50	48	hours	27	mg/L				○		4 OECD SIDS (HPVC)	2	Hüls AG	Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna.	Report No. DK-654 (unpublished).	1995	2017/02/21
甲殻類	Daphnia magna	immoble	EC100	48	hours	73	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
甲殻類	Daphnia magna	immobilization	EC0	48	hours	18	mg/L				○		4 OECD SIDS (HPVC)	2	Hüls AG	Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna.	Report No. DK-654 (unpublished).	1995	2017/02/21
甲殻類	Daphnia magna	immoble	EC0	24	hours	37	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
甲殻類	Daphnia magna		EC50	24	hours	83.7	mg/L				×		11 Japan チャレンジプログラム		Huels Untersuchung				2017/01/30
甲殻類	Daphnia magna	immoble	EC0	48	hours	19	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
甲殻類	Daphnia magna		EC50	24	hours	84	mg/L				○		4 OECD SIDS (HPVC)	4	Hüls AG	Daphnientest nach DIN 38412 Teil 11, Produkt Isophorondiisocyanat.	Report No. D-310a (unpublished, 1 p).	1988	2017/02/21
甲殻類	Daphnia magna	immoble	EC100	24	hours	>73	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
甲殻類	Daphnia magna	Immobilization：遊泳阻害	EC50	2	days	27000	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
甲殻類	Daphnia magna	immoble	EC50	48	hours	35	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
甲殻類	Daphnia magna	Immobilization：遊泳阻害	EC50	2	days	35000	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
甲殻類	Daphnia magna	mobility	EC100	48	hours	>65	mg/L	dissolved			○		12 ECHA Information on Registered Substances	2	study report			1995	2017/02/27
甲殻類	Daphnia magna	mobility	EC50	48	hours	27	mg/L	dissolved			○		12 ECHA Information on Registered Substances	2	study report			1995	2017/02/27
甲殻類	Daphnia magna	mobility	EC0	48	hours	18	mg/L	dissolved			○		12 ECHA Information on Registered Substances	2	study report			1995	2017/02/27
甲殻類	Daphnia magna	mobility	EC100	48	hours	73	mg/L				○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
甲殻類	Daphnia magna	mobility	EC50	24	hours	49	mg/L	dissolved			○		12 ECHA Information on Registered Substances	2	study report			1995	2017/02/27
甲殻類	Daphnia magna	reproduction	LOEC	21	days	10	mg/L				○		12 ECHA Information on Registered Substances	1	study report			1993	2017/02/27
甲殻類	Daphnia magna	reproduction	NOEC	21	days	3	mg/L				○		12 ECHA Information on Registered Substances	1	study report			1993	2017/02/27
魚類	Leuciscus idus (Orfe)		LC50	48	hours	1.8	mg/L						18 既存化学物質安全性(ハザード)評価シート		EU		IUCLID(International Uniform Chemical Information Data Base)Data Set	2000	2016/02/26
魚類	Danio rerio (Zebrafish)	mortality	LC0	96	hours	>=72	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
魚類	Danio rerio (Zebrafish)	mortality	LC50	96	hours	>72	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			2000	2017/02/27
魚類	Cyprinus carpio (Carp)	mortality	LC50	96	hours	>208	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			1996	2017/02/27
魚類	Danio rerio (Zebrafish)	mortality and visible effects (swimming behavior)	LC0	96	hours	>=72	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
魚類	Leuciscus idus (Orfe)	mortality	LC50	48	hours	1.8	mg/L				×		4 OECD SIDS (HPVC)	4	ECB (European Commission - European Chemicals Bureau)	IUCLID Dataset on 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate,	18th February	2000	2017/02/21
魚類	Leuciscus idus (Orfe)	mortality	LC0	48	hours	1	mg/L				×		4 OECD SIDS (HPVC)	4	ECB (European Commission - European Chemicals Bureau)	IUCLID Dataset on 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate,	18th February	2000	2017/02/21
魚類	Danio rerio (Zebrafish)	mortality and visible effects (swimming behavior)	LC50	96	hours	>72	mg/L				○		4 OECD SIDS (HPVC)	2	Bayer AG	Investigation of the ecological properties of DESMODUR I.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2000	2017/02/21
魚類	Cyprinus carpio (Carp)	mortality	LC0	96	hours	>=208	mg/L				○		4 OECD SIDS (HPVC)	2	Hüls AG	Bestimmung der akuten Wirkungen von Vestanat IPDI gegenüber Fischen.	Report No. FK 1369 (unpublished)	1996	2017/02/21
魚類	Cyprinus carpio (Carp)	mortality	LC50	96	hours	>208	mg/L				○		4 OECD SIDS (HPVC)	2	Hüls AG	Bestimmung der akuten Wirkungen von Vestanat IPDI gegenüber Fischen.	Report No. FK 1369 (unpublished)	1996	2017/02/21
魚類	Danio rerio (Zebrafish)	Mortality：死亡	LC50	4	days	>72000	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
魚類	Leuciscus idus (Orfe)		LC0	48	hours	1	mg/L				×		11 Japan チャレンジプログラム		Huels Untersuchung				2017/01/30
魚類	Cyprinus carpio (Carp)	Mortality：死亡	LC50	4	days	>208000	μg/L						6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価）	2	OECD High Production Volume Chemicals Program	SIDS(Screening Information Data Set) Initial Assessment Report, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.	Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).	2006	2017/01/23
魚類	Leuciscus idus (Orfe)		LC50	48	hours	1.8	mg/L				×		11 Japan チャレンジプログラム		Huels Untersuchung				2017/01/30
魚類	Leuciscus idus (Orfe)		LC50	48	hours	1.8	mg/L				×		12 ECHA Information on Registered Substances	4	other company data			1993	2017/03/16
魚類	Cyprinus carpio (Carp)	mortality	LC0	96	hours	>=208	mg/L	TOC measurement			○		12 ECHA Information on Registered Substances	2	study report			1996	2017/02/27
魚類	Leuciscus idus (Orfe)		LC0	48	hours	1	mg/L				×		12 ECHA Information on Registered Substances	4	other company data			1993	2017/03/16