生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 532-32-1
官報公示整理番号　METI No. ： 3-1293/3-1272
物質名 test material ： ナトリウム＝ベンゾアート　／Sodium benzoate
水溶解度 water solubility ： 556000mg/L (推計値 estimated)
LogKow ： -2.27 (推計値 estimated)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Pseudokirchneriella subcapitata Yield inhibition EyC50 72 hours 24.8 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2010 2017/02/27
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours >30.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2010 2017/02/27
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 0.09 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2010 2017/02/27
藻類 Pseudokirchneriella subcapitata growth rate EC10 72 hours 6.5 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2010 2017/02/27
藻類 Pseudokirchneriella subcapitata Yield inhibition NOEyC 72 hours 0.09 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2010 2017/02/27
甲殻類 Daphnia magna Physiology NOEC 2 days <650000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Anderson,B.G. The Toxicity Thresholds of Various Sodium Salts Determined by the Use of Daphnia magna Sewage Works J.18(1): 82-87 1946 2017/03/15
甲殻類 Daphnia magna Mortality LC50 4 days >100000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Ewell,W.S., J.W. Gorsuch, R.O. Kringle, K.A. Robillard, and R.C. Spiegel Simultaneous Evaluation of the Acute Effects of Chemicals on Seven Aquatic Species Environ. Toxicol. Chem.5(9): 831-840 1986 2017/03/15
甲殻類 Daphnia magna Physiology NOEC 2 days <650000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Anderson,B.G. The Toxicity Thresholds of Various Sodium Salts Determined by the Use of Daphnia magna Sewage Works J.18(1): 82-87 1946 2016/03/25
甲殻類 Daphnia magna Mortality LC50 4 days >100000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Ewell,W.S., J.W. Gorsuch, R.O. Kringle, K.A. Robillard, and R.C. Spiegel Simultaneous Evaluation of the Acute Effects of Chemicals on Seven Aquatic Species Environ. Toxicol. Chem.5(9): 831-840 1986 2016/03/25
甲殻類 Daphnia magna LC50 96 hours >100 mg/L 15 WHO/IPCS CICAD Ewell WS, Gorsuch JW, Kringle RO, Robillard KA, Spiegel RC Simultaneous evaluation of the acute effects of chemicals on seven aquatic species. Environmental toxicology and chemistry 1986 2017/03/18
甲殻類 Daphnia magna mortality LC50 96 hours >100 mg/L 12 ECHA Information on Registered Substances 2 publication 1986 2017/02/27
甲殻類 Daphnia magna mortality EC50 96 hours >100 mg/L 4 OECD SIDS (HPVC) 2 Ewell, W.S. et al. Environ. Toxicol. Chem. 1986 2017/02/21
甲殻類 Daphnia magna EC50 96 hours >100 mg/L 11 Japan チャレンジプログラム Ewell, W.S. et al Environ. Toxicol. Chem. 5 1986 2017/01/26
甲殻類 Daphnia magna EC50 48 hours <650 mg/L 4 OECD SIDS (HPVC) Ewell, W.S. et al. Environ. Toxicol. Chem. 1986 2017/02/21
甲殻類 Daphnia magna EC50 48 hours <650 mg/L 11 Japan チャレンジプログラム Anderson, B.G Sewage Works J. 18 1946 2017/01/26
甲殻類 Daphnia magna mortality LC50 96 hours >100 mg/L 12 ECHA Information on Registered Substances 2 publication 1986 2017/02/27
魚類 Danio rerio (Zebrafish) Mortality LC50 2 days 461000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Bichara,D., N.B. Calcaterra, S. Arranz, P. Armas, and S.H. Simonetta Set-up of an Infrared Fast Behavioral Assay Using Zebrafish (Danio rerio) Larvae, and Its Application in Compound Biotoxicity Screening J. Appl. Toxicol.34:214-219 2014 2017/03/15
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days >100000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Ewell,W.S., J.W. Gorsuch, R.O. Kringle, K.A. Robillard, and R.C. Spiegel Simultaneous Evaluation of the Acute Effects of Chemicals on Seven Aquatic Species Environ. Toxicol. Chem.5(9): 831-840 1986 2017/03/15
魚類 Danio rerio (Zebrafish) Behavior EC50 2 days 68500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Bichara,D., N.B. Calcaterra, S. Arranz, P. Armas, and S.H. Simonetta Set-up of an Infrared Fast Behavioral Assay Using Zebrafish (Danio rerio) Larvae, and Its Application in Compound Biotoxicity Screening J. Appl. Toxicol.34:214-219 2014 2017/03/15
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 484000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2017/03/15
魚類 Danio rerio (Zebrafish) Behavior EC50 2 days 68500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Bichara,D., N.B. Calcaterra, S. Arranz, P. Armas, and S.H. Simonetta Set-up of an Infrared Fast Behavioral Assay Using Zebrafish (Danio rerio) Larvae, and Its Application in Compound Biotoxicity Screening J. Appl. Toxicol.34:214-219 2014 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 484000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days >100000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Ewell,W.S., J.W. Gorsuch, R.O. Kringle, K.A. Robillard, and R.C. Spiegel Simultaneous Evaluation of the Acute Effects of Chemicals on Seven Aquatic Species Environ. Toxicol. Chem.5(9): 831-840 1986 2016/03/25
魚類 Danio rerio (Zebrafish) Mortality LC50 2 days 461000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Bichara,D., N.B. Calcaterra, S. Arranz, P. Armas, and S.H. Simonetta Set-up of an Infrared Fast Behavioral Assay Using Zebrafish (Danio rerio) Larvae, and Its Application in Compound Biotoxicity Screening J. Appl. Toxicol.34:214-219 2014 2016/03/25
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours >100 mg/L 15 WHO/IPCS CICAD Ewell WS, Gorsuch JW, Kringle RO, Robillard KA, Spiegel RC Simultaneous evaluation of the acute effects of chemicals on seven aquatic species. Environmental toxicology and chemistry 1986 2017/03/18
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours >100 mg/L 12 ECHA Information on Registered Substances 2 publication 1986 2017/02/27
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours 484 mg/L × 12 ECHA Information on Registered Substances 2 Geiger D. L., Brooke L. T. and Call D. J. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) University of Wisconsin. 1985 2017/02/27
魚類 Pimephales promelas (Fathead minnow) EC50 96 hours 484 mg/L 4 OECD SIDS (HPVC) 1 Geiger, D.L. et al. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) Vol. 2, University of Wisconsin 1985 2017/02/21
魚類 Pimephales promelas (Fathead minnow) mortality LC50 96 hours >100 mg/L 4 OECD SIDS (HPVC) 2 Ewell, W.S. et al Environ. Toxicol. Chem. 1986 2017/02/21
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours >100 mg/L 11 Japan チャレンジプログラム Ewell, W.S. et al Environ. Toxicol. Chem. 5 1986 2017/01/26
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 96 hours 574 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Russom, C.L., Bradbury, S.P., Broderius, S.J., Drummond, R.A. and Hammermeister, D.E. PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS) Environmental Toxicology and Chemistry, Vol. 16, No. 5, pp. 948–967. 1997 2017/03/22
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 484 mg/L 15 WHO/IPCS CICAD Geiger DL, Northcott CE, Call DJ, Brooke LT Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas). Vol. II. Superior, WI, University of Wisconsin 1985 2017/03/18
魚類 Danio rerio (Zebrafish) based on gut abnormalities, malformation of pronephros, edema in the pericardial sac and deformed hatching gland as well as reduced reaction on tactile stimulus LOEC 144 hours 100 mg/L 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 96 hours 392.5 mg/L × 12 ECHA Information on Registered Substances 2 Geiger D. L., Brooke L. T. and Call D. J. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) University of Wisconsin. 1985 2017/02/27
魚類 Danio rerio (Zebrafish) mortality LC50 24 hours 1400～1500 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Danio rerio (Zebrafish) based on gut abnormalities, malformation of pronephros, edema in the pericardial sac and deformed hatching gland as well as reduced reaction on tactile stimulus NOEC 144 hours 10 mg/L 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Danio rerio (Zebrafish) mortality LC50 24 hours 1400～1500 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Danio rerio (Zebrafish) based on gut abnormalities, malformation of pronephros, edema in the pericardial sac and deformed hatching gland as well as reduced reaction on tactile stimulus NOEC 144 hours 10 mg/L 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Danio rerio (Zebrafish) based on gut abnormalities, malformation of pronephros, edema in the pericardial sac and deformed hatching gland as well as reduced reaction on tactile stimulus LOEC 144 hours 100 mg/L 12 ECHA Information on Registered Substances 2 publication 2007 2017/02/27
魚類 Pimephales promelas (Fathead minnow) NOEC 96 hours >245 mg/L 4 OECD SIDS (HPVC) 1 Geiger, D.L. et al. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas), Vol. 2, University of Wisconsin 1985 2017/02/21