生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 57-09-0
官報公示整理番号　METI No. ： 9-795/9-1971/1-105/2-184
物質名 test material ： ヘキサデシルトリメチルアンモニウム＝ブロミド　／Cetrimonium bromide
水溶解度 water solubility ： 100000mg/L (推計値 estimated)
LogKow ： 3.18 (推計値 estimated)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Chlorella sp. Population 3 days 18000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Walker,J.R.L., and S. Evans Effect of Quaternary Ammonium Compounds on Some Aquatic Plants Mar. Pollut. Bull.9(5): 136-137 1978 2016/03/25
藻類 Pseudokirchneriella subcapitata Population EC50 4 days 90 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Lewis,M.A., and B.G. Hamm Environmental Modification of the Photosynthetic Response of Lake Plankton to Surfactants and Significance to a Laboratory-Field Comparison Water Res.20(12): 1575-1582 1986 2016/03/25
藻類 Pseudokirchneriella subcapitata Mortality 21 days 2500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Nyberg,H. Growth of Selenastrum capricornutum in the Presence of Synthetic Surfactants Water Res.22(2): 217-223 1988 2016/03/25
藻類 Selenastrum sp. Population EC50 4 days 90 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Lewis,M.A. Comparison of the Effects of Surfactants on Freshwater Phytoplankton Communities in Experimental Enclosures and on Algal Population Growth in the Lab Environ. Toxicol. Chem.5(3): 319-332 1986 2016/03/25
藻類 Scenedesmus sp. Population 10 days 0.7～2900 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Lewis,M.A. Comparison of the Effects of Surfactants on Freshwater Phytoplankton Communities in Experimental Enclosures and on Algal Population Growth in the Lab Environ. Toxicol. Chem.5(3): 319-332 1986 2016/03/25
藻類 Selenastrum capricornutum Growth EC50 96 hours 0.09 mg/L 9 ECETOC Aquatic Toxicity, EAT Lewis and Hamm 86 2016/02/08
藻類 Area under growth curve EC50 72 hours 21 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 growth rate EC50 72 hours 6.4 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours 4.11 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/03/25
藻類 Selenastrum capricornutum 生長阻害　バイオマス EC50 96 hours 0.09 mg/L 8 NITE 化学物質の初期リスク評価書 Lewis, M.A. Comparison of the effects of surfactants on freshwater phytoplankton communities in experimental enclosures and on algal population growth in the laboratory. Environ. Toxicol. Chem.,5 1986 2016/03/10
藻類 Selenastrum capricornutum 生長阻害　バイオマス EC100 3 weeks <=2.5 mg/L 8 NITE 化学物質の初期リスク評価書 Nyberg, H. Growth of Selenastrum capricornutum in the presence of synthetic surfactants. Water Res., 22 1988 2016/03/10
藻類 Pseudokirchneriella subcapitata Growth EC50 4 days 90 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） a Lewis, M.A., and B.G. Hamm Environmental Modification of the Photosynthetic Response of Lake Plankton to Surfactants and Significance to a Laboratory-Field Comparison. Water Res. (U.S.EPA「AQUIRE」) 1986 2016/03/07
藻類 Chlorella sp. 生長阻害　バイオマス EC100 72 hours 0.05 mg/L 8 NITE 化学物質の初期リスク評価書 Walker, J.R.L. and Evans, S. Effect of quaternary ammonium compounds on some aquatic plants. Marine Pollut. Bull., 9 1978 2016/03/10
藻類 Selenastrum capricornutum 生長阻害　バイオマス EC50 96 hours 0.09 mg/L 8 NITE 化学物質の初期リスク評価書 Lewis, M.A. and Hamm, B.G. Environmental modification of the photosynthetic response of lake plankton to surfactants and significance to a laboratory-field comparison. Water Res., 20, 1986 2016/03/10
藻類 Pseudokirchneriella subcapitata EC50 72 hours 0.0064 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
藻類 Pseudokirchneriella subcapitata EC50 72 hours 0.021 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
藻類 Pseudokirchneriella subcapitata growth rate EC50 72 hours 4.11 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/03/24
藻類 growth rate EC50 72 hours 6.4 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 Area under growth curve EC50 72 hours 21 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 growth rate NOEC 72 hours 1.8 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 1.1 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
藻類 growth rate NOEC 72 hours 1.8 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 Area under growth curve NOEC 72 hours 12 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
藻類 Pseudokirchneriella subcapitata growth rate NOEC 72 hours 1.1 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/03/24
藻類 Pseudokirchneriella subcapitata growth rate EC10 72 hours 2.27 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/03/25
藻類 Pseudokirchneriella subcapitata NOEC 72 hours 0.012 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
藻類 Pseudokirchneriella subcapitata NOEC 72 hours 0.0018 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
藻類 Pseudokirchneriella subcapitata growth rate EC10 72 hours 2.27 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/03/24
藻類 Area under growth curve NOEC 72 hours 12 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Environment in Japan (-March 2010) www.env.go.jp/chemi/ 2010 2016/02/15
甲殻類 Daphnia magna reproduction EC50 21 days 0.023～0.04 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/Chemi/ 2010 2016/02/15
甲殻類 Daphnia magna mobility EC50 24 hours 58 μg/L 12 ECHA Information on Registered Substances 2 Sandbacka M, I C hristianson, B. Isomaa The Acute Toxicity of Surfactants on Fish Cells, Daphnia magna and Fish - A Comparative Study Toxicology in Vitro 2000 2016/02/15
甲殻類 Daphnia magna reproduction EC50 21 days 0.023～0.04 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/Chemi/ 2010 2016/02/15
甲殻類 Daphnia magna mobility EC50 24 hours 58 μg/L 12 ECHA Information on Registered Substances 2 Sandbacka M, I C hristianson, B. Isomaa The Acute Toxicity of Surfactants on Fish Cells, Daphnia magna and Fish - A Comparative Study Toxicology in Vitro 2000 2016/02/15
甲殻類 Daphnia magna mobility immobility EC10 48 hours 21 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
甲殻類 Daphnia magna mobility IC50 24 hours 0.13 μg/L 12 ECHA Information on Registered Substances 2 Garcia MT, I Ribosa, T Guindulain, J Sánchez-Leal, J Vives-Rego Fate and effect of monoalkyl quaternary ammonium surfactants in the aquatic environment Environmental Pollution 2001 2016/02/15
甲殻類 Daphnia magna EC50 48 hours 16 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/chemi/ 2007 2016/02/15
甲殻類 Daphnia magna mobility IC50 24 hours 0.13 μg/L 12 ECHA Information on Registered Substances 2 Garcia MT, I Ribosa, T Guindulain, J Sánchez-Leal, J Vives-Rego Fate and effect of monoalkyl quaternary ammonium surfactants in the aquatic environment Environmental Pollution 2001 2016/02/15
甲殻類 Daphnia magna mobility immobility EC50 48 hours 26 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
甲殻類 Daphnia magna 遊泳阻害 EC50 24 hours 0.22 mg/L 8 NITE 化学物質の初期リスク評価書 Leal, J.S., Gonzalez, J.J., Kaiser, K.L.E., Palabrica, V.S., Comelles, F. and Garcia, M.T. On the toxicity and biodegradation of cationic surfactants. Acta Hydrochim. Hydrobiol., 22 1994 2016/03/10
甲殻類 Ceriodaphnia dubia LC50 48 hours 0.5 mg/L 8 NITE 化学物質の初期リスク評価書 Schlumberger Technology Corp. 48-Hour freshwater acute toxicity test and Kow estimation of bromat (cetyl trimethylammonium bromide). Stover & Associates Inc., EPA Doc. I.D.88960000173, OTS0558566. 1996 2016/03/10
甲殻類 Daphnia magna EC50 48 hours 0.016 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
甲殻類 Daphnia magna EC50 48 hours 16 μg/L ○ 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/chemi/ 2007 2016/02/15
甲殻類 Daphnia magna mobility immobility EC10 48 hours 21 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
甲殻類 Daphnia magna mobility immobility EC50 48 hours 26 μg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
甲殻類 Daphnia magna NOEC 21 days 0.023 μg/L 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/Chemi/ 2010 2016/02/15
甲殻類 Daphnia magna EC50 21 days 0.023～0.04 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
甲殻類 Daphnia magna NOEC 21 days 0.023 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
甲殻類 Daphnia magna NOEC 21 days 0.023 μg/L 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/Chemi/ 2010 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality (High TOC , river water) LC50 96 hours 0.26 mg/L × 12 ECHA Information on Registered Substances 2 Versteeg,DJ.; Shorter,SJ. Effects of organic carbon on the uptake and toxicity of quarternary ammoniumm compounds to the fathead minnow pimephales promelas Environmental Toxicology and Chemistry 1992 2016/02/15
魚類 Danio rerio (Zebrafish) mortality LC50 96 hours 0.2 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
魚類 Danio rerio (Zebrafish) mortality LC10 96 hours 0.17 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality (High TOC , river water) LC50 96 hours 0.26 mg/L × 12 ECHA Information on Registered Substances 2 Versteeg,DJ.; Shorter,SJ. Effects of organic carbon on the uptake and toxicity of quarternary ammoniumm compounds to the fathead minnow pimephales promelas Environmental Toxicology and Chemistry 1992 2016/02/15
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 0.28 mg/L 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/C hemi/sesaku/02e.pdf 2010 2016/02/15
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 24 hours 0.6 mg/L × 12 ECHA Information on Registered Substances 2 Sandbacka M, I C hristianson, B. Isomaa The Acute Toxicity of Surfactants on Fish Cells, Daphnia magna and Fish - A Comparative Study Toxicology in Vitro 2000 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality (Low TOC, well water with added humic acid) LC50 96 hours 0.1 mg/L × 12 ECHA Information on Registered Substances 2 Versteeg,DJ.; Shorter,SJ. Effects of organic carbon on the uptake and toxicity of quarternary ammoniumm compounds to the fathead minnow pimephales promelas Environmental Toxicology and Chemistry 1992 2016/02/15
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 0.28 mg/L 1 日本環境省　生態リスク初期評価 環境省 （Ⅱ-1）生態影響試験（藻類、甲殻類、魚類）結果一覧(平成27年3月版） 2016/11/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 24 hours 0.6 mg/L × 12 ECHA Information on Registered Substances 2 Sandbacka M, I C hristianson, B. Isomaa The Acute Toxicity of Surfactants on Fish Cells, Daphnia magna and Fish - A Comparative Study Toxicology in Vitro 2000 2016/02/15
魚類 Danio rerio (Zebrafish) mortality LC50 96 hours 0.2 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality (Low TOC, well water with added humic acid) LC50 96 hours 0.1 mg/L × 12 ECHA Information on Registered Substances 2 Versteeg,DJ.; Shorter,SJ. Effects of organic carbon on the uptake and toxicity of quarternary ammoniumm compounds to the fathead minnow pimephales promelas Environmental Toxicology and Chemistry 1992 2016/02/15
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 0.28 mg/L 12 ECHA Information on Registered Substances 2 Ministry of the Environment in Japan Results of Eco-toxicity test of chemicals conducted by the Ministry of the Enviroment in Japan (-March 2010) www.env.go.jp/C hemi/sesaku/02e.pdf 2010 2016/02/15
魚類 Danio rerio (Zebrafish) mortality LC10 96 hours 0.17 mg/L ○ 12 ECHA Information on Registered Substances 1 study report 2007 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 35 days 0.053 mg/L 12 ECHA Information on Registered Substances 2 Lewis,MA.; Wee,VT. Aquatic safety assessment for cationic sufactants Environmental Toxicology and Chemistry 1983 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 35 days 0.23 mg/L 12 ECHA Information on Registered Substances 2 Lewis,MA.; Wee,VT. Aquatic safety assessment for cationic sufactants Environmental Toxicology and Chemistry 1983 2016/02/15
魚類 others Pimephales sp. NOEC 0.46 mg/L 12 ECHA Information on Registered Substances 3 Pittinger C A, DM Woltering, JA Masters Bioavailability of sediment-sorbed and aqueous surfactants to Chironomus riparius (midge) Environmental Toxicology and Chemistry 1989 2016/02/15
魚類 others Pimephales sp. NOEC 0.46 mg/L 12 ECHA Information on Registered Substances 3 Pittinger C A, DM Woltering, JA Masters Bioavailability of sediment-sorbed and aqueous surfactants to Chironomus riparius (midge) Environmental Toxicology and Chemistry 1989 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 35 days 0.053 mg/L 12 ECHA Information on Registered Substances 2 Lewis,MA.; Wee,VT. Aquatic safety assessment for cationic sufactants Environmental Toxicology and Chemistry 1983 2016/02/15
魚類 Pimephales promelas (Fathead minnow) mortality NOEC 35 days 0.23 mg/L 12 ECHA Information on Registered Substances 2 Lewis,MA.; Wee,VT. Aquatic safety assessment for cationic sufactants Environmental Toxicology and Chemistry 1983 2016/02/15