生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 6419-19-8
官報公示整理番号　METI No. ： 2-2009/2-1866
物質名 test material ： ニトリロ　トリス　メチレン　ホスホン酸　／Phosphonic acid, [nitrilotris(methylene)]tris-
水溶解度 water solubility ： 1000000mg/L (推計値 estimated)
LogKow ：
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Chlorella sp. EC50 14 days 20 mg/L × 4 OECD SIDS (HPVC) 4 IUCLID CD ROM CAS No: 6419-19-8. Monsanto unpublished studies report AB-79-1384338-2. 2000 2017/02/26
藻類 Selenastrum capricornutum biomass EC50 96 hours 33.88～62.81 ○ 4 OECD SIDS (HPVC) 2 Monsanto Project No: 43-000-755.10-168. Determination of toxic and/or lethal effects of phosphonates on Selenastrum capricornutum as influenced by media, pH and hardness. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: MO ESC9271. 1992 2017/02/26
藻類 Selenastrum capricornutum biomass EC50 96 hours 19.6 mg/L as active acid × 4 OECD SIDS (HPVC) 4 Schowanek D. & Verstraete W. J.Environ.Quality 1991 2017/02/26
藻類 Chlorella sp. growth rate EC50 96 hours 100 mg/L × 4 OECD SIDS (HPVC) 4 IUCLID CD ROM CAS No: 6419-19-8. Monsanto report BN-76-0090c. 2000 2017/02/26
藻類 Selenastrum capricornutum biomass EC50 96 hours 12.39～19.14 ○ 4 OECD SIDS (HPVC) 2 Monsanto Project No: 43-000-755.10-168. Determination of toxic and/or lethal effects of phosphonates on Selenastrum capricornutum as influenced by media, pH and hardness. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: MO ESC9271. 1992 2017/02/26
藻類 Pseudokirchneriella subcapitata biomass EC50 96 hours 12.39 mg/L ○ 12 ECHA Information on Registered Substances 2 study report 1992 2017/02/09
藻類 Selenastrum sp. cell number NOEC 14 days 100 mg/L ○ 12 ECHA Information on Registered Substances 4 grey literature 1984 2017/02/09
藻類 Anabaena sp. biomass LOEC 18 days 100 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
藻類 Anabaena sp. biomass NOEC 18 days 10 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
藻類 Pseudokirchneriella subcapitata LOEC 14 days 300 mg/L 12 ECHA Information on Registered Substances 4 Schöberl P, Huber L Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Surfactants Detergents 1988 2017/02/09
藻類 Selenastrum sp. biomass LOEC 18 days 10 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
藻類 Selenastrum sp. biomass NOEC 18 days <10 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
藻類 Pseudokirchneriella subcapitata biomass EC50 14 days 19.6 mg/L × 12 ECHA Information on Registered Substances 2 study report 1980 2017/02/09
藻類 Pseudokirchneriella subcapitata biomass NOEC 14 days 7.4 mg/L × 12 ECHA Information on Registered Substances 2 study report 1980 2017/02/09
藻類 Anabaena sp. biomass LOEC 18 days 100 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Anabaena sp. biomass NOEC 18 days 10 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Selenastrum sp. biomass LOEC 18 days 10 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Chlorella sp. biomass LOEC 18 days 10 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Chlorella sp. biomass NOEC 18 days <10 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Selenastrum sp. biomass NOEC 18 days <10 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job Number: 03-000-760, 117031-K3. Project No: MO-76-347. Dequest - Algae Part II. Unpublished progress report for Monsanto Company, St Louis, MO. 1972 2017/02/26
藻類 Selenastrum capricornutum NOEC 14 days 100 mg/L 4 OECD SIDS (HPVC) 4 Schöberl P. and Huber L. Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Surfactants Detergents 1988 2017/02/26
藻類 Selenastrum capricornutum LOEC 14 days 300 mg/L 4 OECD SIDS (HPVC) 4 Schöberl P. and Huber L. Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Surfactants Detergents 1988 2017/02/26
藻類 Selenastrum capricornutum biomass NOEC 96 hours 7.4 mg/L as active acid × 4 OECD SIDS (HPVC) 4 IUCLID CD ROM CAS No: 6419-19-8. Monsanto report BN-76-0090c. 2000 2017/02/26
藻類 Pseudokirchneriella subcapitata NOEC 14 days 100 mg/L 12 ECHA Information on Registered Substances 4 Schöberl P, Huber L Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Surfactants Detergents 1988 2017/02/09
藻類 Chlorella sp. biomass LOEC 18 days 10 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
藻類 Chlorella sp. biomass NOEC 18 days <10 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
甲殻類 Daphnia magna immobility EC50 24 hours 375 mg/L act. ingr. × 12 ECHA Information on Registered Substances 4 study report 1972 2017/02/09
甲殻類 Daphnia magna mobility EC50 48 hours 883 mg/L act. ingr. 12 ECHA Information on Registered Substances 4 study report 1976 2017/02/09
甲殻類 Daphnia magna EC100 24 hours 450 mg/L × 12 ECHA Information on Registered Substances 4 study report 1972 2017/02/09
甲殻類 Daphnia magna EC0 24 hours 300 mg/L × 12 ECHA Information on Registered Substances 4 study report 1972 2017/02/09
甲殻類 Daphnia magna immobility EC50 24 hours 545 mg/L act. ingr. × 12 ECHA Information on Registered Substances 2 study report 1981 2017/02/09
甲殻類 Daphnia magna EC50 24 hours 1182 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job No: 45-000-760.40-6956000. Acute and chronic toxicity tests on Daphnia with DEQUEST Phosphonates. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: MO-77-0468-0469. 1976 2017/02/26
甲殻類 Daphnia magna EC50 48 hours 833 mg/L × 4 OECD SIDS (HPVC) 4 Monsanto Job No: 45-000-760.40-6956000. Acute and chronic toxicity tests on Daphnia with DEQUEST Phosphonates. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: MO-77-0468-0469. 1976 2017/02/26
甲殻類 Daphnia magna EC50 24 hours 188 mg/L × 4 OECD SIDS (HPVC) 2 Henkel Aminotris(methylen-phosphonsaeure) (CA 3) Pruefung auf allergieausloesende Eigenschaften am Meerschweinchen Abschlussbericht. Henkel Institut fuer Toxicologie, January 1984 1984 2017/02/26
甲殻類 Daphnia magna EC50 48 hours 297 mg/L × 4 OECD SIDS (HPVC) 2 Monsanto Acute toxicity of Dequest 2000, 2010, 2041, 2051 and 2060 to Daphnia magna. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: ES-81-SS-13. 1981 2017/02/26
甲殻類 Daphnia magna EC0 24 hours 150 mg/L × 4 OECD SIDS (HPVC) 2 Henkel Aminotris(methylen-phosphonsaeure) (CA 3) Pruefung auf allergieausloesende Eigenschaften am Meerschweinchen Abschlussbericht. Henkel Institut fuer Toxicologie, January 1984 1984 2017/02/26
甲殻類 Daphnia magna EC100 24 hours 225 mg/L × 4 OECD SIDS (HPVC) 2 Henkel Aminotris(methylen-phosphonsaeure) (CA 3) Pruefung auf allergieausloesende Eigenschaften am Meerschweinchen Abschlussbericht. Henkel Institut fuer Toxicologie, January 1984 1984 2017/02/26
甲殻類 Daphnia magna EC50 48 hours 833 mg/L × 12 ECHA Information on Registered Substances 4 study report 1976 2017/02/09
甲殻類 Daphnia magna EC0 24 hours 300 mg/L 12 ECHA Information on Registered Substances 4 Schöberl P, Huber L Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Surfactants Detergents 1988 2017/02/09
甲殻類 Daphnia magna immobility EC50 48 hours 297 mg/L act. ingr. × 12 ECHA Information on Registered Substances 2 study report 1981 2017/02/09
甲殻類 Daphnia magna adult survival and reproduction (no. of offspring) NOEC 28 days >=25 mg/L act. ingr. 12 ECHA Information on Registered Substances 2 study report 1976 2017/02/09
甲殻類 Daphnia magna immobility NOEC 48 hours 125 mg/L act. ingr. × 12 ECHA Information on Registered Substances 2 study report 1981 2017/02/09
甲殻類 Daphnia magna NOEC 21 days 3 mg/L × 12 ECHA Information on Registered Substances 4 grey literature 1984 2017/02/09
甲殻類 Daphnia magna NOEC 48 hours 125 mg/L × 4 OECD SIDS (HPVC) 2 Monsanto Acute toxicity of Dequest 2000, 2010, 2041, 2051 and 2060 to Daphnia magna. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: ES-81-SS-13. 1981 2017/02/26
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours >330 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours >330 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 14 days 150 mg/L act. ingr. ○ 12 ECHA Information on Registered Substances 1 study report 1979 2017/02/09
魚類 Leuciscus idus (Orfe) LC50 48 hours 250 mg/L × 12 ECHA Information on Registered Substances 4 Kastner W von, Gode P Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/09
魚類 Leuciscus idus (Orfe) LC0 48 hours 191 mg/L × 12 ECHA Information on Registered Substances 4 Kastner W von, Gode P Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality LC50 96 hours 160 mg/L act. ingr. ○ 12 ECHA Information on Registered Substances 1 study report 1979 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours >330 mg/L × 4 OECD SIDS (HPVC) 2 Industrial BIO-TEST laboratories Inc. Request No BTL-71-51. Four-day static fish toxicity studies with Dequest 2000 in rainbow trout and bluegills. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: BT-71-0051. 1972 2017/02/26
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours >330 mg/L × 4 OECD SIDS (HPVC) 2 Industrial BIO-TEST laboratories Inc. Request No BTL-71-51. Four-day static fish toxicity studies with Dequest 2000 in rainbow trout and bluegills. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: BT-71-0051. 1972 2017/02/26
魚類 Leuciscus idus (Orfe) LC0 48 hours 191 mg/L as active acid × 4 OECD SIDS (HPVC) 4 Kastner, W. von and Gode, P. Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/26
魚類 Leuciscus idus (Orfe) LC0 48 hours 125 mg/L × 4 OECD SIDS (HPVC) 4 Henkel KGaA Unpublished data, Archive No.830091. Cited in European Chemicals Bureau IUCLID data sheet for CAS No 6419-19-8 1983 2017/02/26
魚類 Leuciscus idus (Orfe) LC50 48 hours 250 mg/L as active acid × 4 OECD SIDS (HPVC) 4 Kastner, W. von and Gode, P. Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/26
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 14 days 150 mg/L ○ 4 OECD SIDS (HPVC) 1 ABC Dynamic toxicity of Dequest 2000 (AB-79-1384338-1) in Rainbow Trout (Salmo gairdneri). Unpublished report for Monsanto Chemical Company, St Louis MO. Monsanto Report No: AB-79-0191. 1979 2017/02/26
魚類 Cyprinodon variegatus (Sheepshead minnow) LC0 96 hours 8132 mg/L × 12 ECHA Information on Registered Substances 2 study report 1976 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) length and weight of fry NOEC 60 days 23 mg/L act. ingr. ○ 12 ECHA Information on Registered Substances 1 study report 1980 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) length and weight of fry LOEC 60 days 47.6 mg/L act. ingr. ○ 12 ECHA Information on Registered Substances 1 study report 1980 2017/02/09
魚類 Leuciscus idus (Orfe) NOEC 48 hours 150 mg/L × 12 ECHA Information on Registered Substances 4 Kastner W von, Gode P Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) NOEC 96 hours 330 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
魚類 Oncorhynchus mykiss (Rainbow trout) mortality NOEC 14 days 47 mg/L act. ingr. ○ 12 ECHA Information on Registered Substances 1 study report 1979 2017/02/09
魚類 Lepomis macrochirus (Bluegill) NOEC 96 hours 330 mg/L × 12 ECHA Information on Registered Substances 2 study report 1972 2017/02/09
魚類 Lepomis macrochirus (Bluegill) NOEC 96 hours 330 mg/L × 4 OECD SIDS (HPVC) 2 Industrial BIO-TEST laboratories Inc. Request No BTL-71-51. Four-day static fish toxicity studies with Dequest 2000 in rainbow trout and bluegills. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: BT-71-0051. 1972 2017/02/26
魚類 Leuciscus idus (Orfe) NOEC 48 hours 150 mg/L as active acid × 4 OECD SIDS (HPVC) 4 Kastner, W. von and Gode, P. Method und Ergebnisse bei der toxicologischen und okologischen Prufung von Wasserbehandlungsmitteln. Z. Wasser Abwasser Forsch. 1983 2017/02/26
魚類 Oncorhynchus mykiss (Rainbow trout) NOEC 96 hours 330 mg/L × 4 OECD SIDS (HPVC) 2 Industrial BIO-TEST laboratories Inc. Request No BTL-71-51. Four-day static fish toxicity studies with Dequest 2000 in rainbow trout and bluegills. Unpublished report for Monsanto Company, St Louis, MO. Monsanto Report No: BT-71-0051. 1972 2017/02/26
魚類 Oncorhynchus mykiss (Rainbow trout) NOEC 14 days 47 mg/L ○ 4 OECD SIDS (HPVC) 1 ABC Dynamic toxicity of Dequest 2000 (AB-79-1384338-1) in Rainbow Trout (Salmo gairdneri). Unpublished report for Monsanto Chemical Company, St Louis MO. Monsanto Report No: AB-79-0191. 1979 2017/02/26
魚類 Cyprinodon variegatus (Sheepshead minnow) NOEC 96 hours 4831 mg/L × 12 ECHA Information on Registered Substances 2 study report 1976 2017/02/09