生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 88-73-3
官報公示整理番号　METI No. ： 3-442
物質名 test material ： １－クロロ－２－ニトロベンゼン　／1-Chloro-2-nitrobenzene
水溶解度 water solubility ： 441mg/L (推計値 estimated)
LogKow ： 2.24 (実測値 measured)
備考 remarks ：
Excelファイルダウンロード

【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Desmodesmus subspicatus biomass EC50 48 hours 34 mg/L 4 OECD SIDS (HPVC) 2 Kuehn, R. and Pattard, M. Water Research 24 (1) 1990 2023/02/08
藻類 Desmodesmus subspicatus growth rate EC50 48 hours 75 mg/L nominal test mat. 12 ECHA Information on Registered Substances 2 Kuehn R, Pattard M Results of the harmful effects of water
pollutants to the green algae (Scenedesmus
subspicatus) in the cell
multiplication inhibition test.
 Water Res. 24(1), 31-38. 1990 2022/08/10
藻類 Chlorella pyrenoidosa biomass ErC50 96 hours 6.9 mg/L 14 BUA Report Maas-Diepeveen JL, van Leeuwen CJ Aquatic toxicity of aromatic nitro compounds and
anillines to several freshwater species		 Laboratory for Ecotoxicology, Institute for
Inland Water Management and Waste Water
Treatment, Report No. 86-42		 1986 2023/02/21
藻類 Desmodesmus subspicatus growth rate EC50 48 hours 75 mg/L 4 OECD SIDS (HPVC) 2 Kuehn, R. and Pattard, M. Water Research 24 (1) 1990 2023/02/08
藻類 Chlorella pyrenoidosa biomass EC50 96 hours 6.88 mg/L test mat. 12 ECHA Information on Registered Substances 2 study report 1986 2022/08/10
藻類 Desmodesmus subspicatus biomass EC50 48 hours 34 mg/L nominal test mat. 12 ECHA Information on Registered Substances 2 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
藻類 Scenedesmus obliquus growth rate EC50 96 hours 18.1 mg/L test mat. × 12 ECHA Information on Registered Substances 2 Zhao Y-H, Yuan X, Ji G-D, Sheng L-X, Wang L-S Quantitative Structure-Activity Relationships of
Nitroaromatic Compounds to Four Aquatic
Organisms. 		Chemosphere 34 (8): 1837 - 1844 1997 2022/08/10
藻類 Scenedesmus pannonicus growth rate EC50 72 hours 24 mg/L ○ 4 OECD SIDS (HPVC) 3 Canton, J.H. et al. Regul. Toxicol. Pharmacol. 5 1985 2023/01/18
藻類 Scenedesmus obliquus growth rate EC50 96 hours 18.1 mg/L 4 OECD SIDS (HPVC) 2 Zhao, Y.-H. et al. Quantitative Structure-Activity Relationships of
Nitroaromatic compounds to Four Aquatic
Organisms		 Chemosphere, Vol. 34, 8 1997 2023/01/18
藻類 Desmodesmus subspicatus Population/Population growth rate EC50 48 hours 75 Formulation × 16 ECOTOX Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1) 1990 2022/09/15
藻類 Chlorella pyrenoidosa biomass EC50 96 hours 6.9 mg/L 4 OECD SIDS (HPVC) 2 Deneer, J.W. et al. QSAR study of the toxicity of nitrobenzene
derivatives towards Daphnia magna, Chlorella
pyrenoidosa and Photobacterium
phosphoreum		 Aquatic Toxicology, 15 1989 2023/02/20
藻類 Chlorella pyrenoidosa Reproduction/Progeny counts/numbers EC50 96 hours 6900 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
藻類 Desmodesmus pannonicus biomass EbC50 暴露期間不明 24 mg/L nominal 14 BUA Report Canton JH, Slooff W, Kool HJ, Struvs J, Pouw TJM,
Wegman RCC, Piet GJ		 Toxicity, biodegradability and accumulation of a
number of Cl/N-containing compounds for
classification and establishing water quality
criteria		 Regul Toxicol Pharm 5 1985 2023/01/31
藻類 Scenedesmus obliquus ErC50 48 hours 18.1 mg/L effetive 14 BUA Report Liu L, Lang P Toxicities of nitroaromatic compounds to
Scenedesmus obliquus aond toxic symptoms		 Huanjing Kexue 16 1995 2023/01/31
藻類 Desmodesmus subspicatus ErC50 48 hours 75 mg/L nominal × 14 BUA Report Kühn R, Pattard M Result of the harmful effects of water pollutants
to green algae (Scenedesmus subspicatus) in the
cell multiplication inhibition test		 Wat Res 24(1) 1990 2023/02/21
藻類 Scenedesmus vacuolatus ErC50 24 hours 23.8 mg/L 14 BUA Report Schmitt H, Altenburger R, Jastirff B, Schüürmann
G		 Quantitatve structure-activity analysis of the
algae toxicity of nitroaromatic compounds		 Chem Res Toxicol 13 2000 2023/01/31
藻類 Desmodesmus subspicatus Population/Biomass EC50 48 hours 34 Formulation × 16 ECOTOX Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1) 1990 2022/09/15
藻類 Desmodesmus subspicatus growth rate EC10 48 hours 19 mg/L 4 OECD SIDS (HPVC) 2 Kuehn, R. and Pattard, M. Water Research 24 (1) 1990 2023/02/08
藻類 Desmodesmus subspicatus biomass EC10 48 hours 11 mg/L nominal test mat. 12 ECHA Information on Registered Substances 2 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
藻類 Desmodesmus subspicatus Population/Biomass EC10 48 hours 11 Formulation × 16 ECOTOX Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1) 1990 2022/09/15
藻類 Desmodesmus subspicatus ErC10 48 hours 19 mg/L nominal × 14 BUA Report Kühn R, Pattard M Result of the harmful effects of water pollutants
to green algae (Scenedesmus subspicatus) in the
cell multiplication inhibition test		 Wat Res 24(1) 1990 2023/01/31
藻類 Desmodesmus subspicatus Population/Population growth rate EC10 48 hours 19 Formulation × 16 ECOTOX Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1) 1990 2022/09/15
藻類 Desmodesmus subspicatus Population/Photosynthesis NOEC >=49～<=79 minutes >=250 Formulation × 16 ECOTOX Nendza,M., and A. Wenzel Discriminating Toxicant Classes by Mode of Action
1. (Eco)toxicity Profiles		 Environ. Sci. Pollut. Res.13(3) 2006 2022/09/15
藻類 Desmodesmus subspicatus biomass EC10 48 hours 11 mg/L 4 OECD SIDS (HPVC) 2 Kuehn, R. and Pattard, M. Water Research 24 (1) 1990 2023/02/08
藻 類 Chlorella pyrenoidosa growth (Yield) EC50 4 days 6900 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Maas-Diepeveen, J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Laboratory for Ecotoxicology, Institute for
Inland Water Management and Waste Water
Treatment, Report No.86-42		 1986 2022/07/21
藻 類 Desmodesmus pannonicus growth EC50 3 days 24000 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Canton, J.H., W. Slooff, H.J. Kool, J. Struys, Th.
J.M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul.Toxicol.Pharmacol.5 1985 2022/07/21
藻 類 Scenedesmus acutus var. acutus growth (RATE) EC50 2 days 18100 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Zhao, Y., X.Yuan, G. Ji G and L. Sheng Quantitative Structure-Activity Relationships of
Nitroaromatic Compounds to Four Aquatic
Organisms		 Chemosphere 34 (8) 1997 2022/07/21
甲殻類 Daphnia magna LC50 48 hours 49 mg/L × 12 ECHA Information on Registered Substances 3 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
甲殻類 Daphnia magna EC0 24 hours 5 mg/L × 12 ECHA Information on Registered Substances 3 study report 1988 2022/08/10
甲殻類 Daphnia magna EC50 24 hours 12 mg/L test mat. 12 ECHA Information on Registered Substances 2 secondary source 2001 2022/08/10
甲殻類 Daphnia carinata mobility IC50 48 hours 21.3 mg/L test mat. × 12 ECHA Information on Registered Substances 2 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
甲殻類 Daphnia magna EC50 24 hours 12 mg/L × 4 OECD SIDS (HPVC) 2 Kuehn, R. et al. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fuer
die Bewertung der Umweltvertraeglichkeit
in aquatischen Systemen		 UFOPLAN Nr. 106 03 052 des BMU, Maerz 1988 2023/01/18
甲殻類 Daphnia magna LC50 48 hours 49 mg/L × 4 OECD SIDS (HPVC) 3 Canton, J.H. et al. Regul. Toxicol. Pharmacol. 5 1985 2023/01/18
甲殻類 Daphnia magna EC0 24 hours 5 mg/L × 4 OECD SIDS (HPVC) 2 Kuehn, R. et al. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fuer
die Bewertung der Umweltvertraeglichkeit
in aquatischen Systemen		 UFOPLAN Nr. 106 03 052 des BMU, Maerz 1988 2023/01/18
甲殻類 Daphnia magna Intoxication/Immobile EC0 24 hours 5 Formulation × 16 ECOTOX Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4) 1998 2022/09/15
甲殻類 Daphnia magna Immobilization EC50 2 days 3200 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Canton, J.H., W. Slooff, H.J. Kool, J. Struys, Th.
J.M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul.Toxicol.Pharmacol.5 1985 2022/07/21
甲殻類 Daphnia carinata EC50 48 hours 21.3 mg/L 4 OECD SIDS (HPVC) 2 Zhao, Y.-H. et al. Quantitative Structure-Activity Relationships of
Nitroaromatic compounds to Four Aquatic
Organisms		 Chemosphere, Vol. 34, 8 1997 2023/01/18
甲殻類 Daphnia carinata EC50 48 hours 21.3 mg/L nominal × 14 BUA Report Zhao YH, Yuan X, Ji GD, Sheng LX Quantitative structure-activity relationships of
nitroaromatic compounds to four aquatic
organisms		 Chemosphere 34 1997 2023/01/31
甲殻類 Daphnia carinata Immobilization EC50 2 days 21300 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Zhao, Y., X.Yuan, G. Ji G and L. Sheng Quantitative Structure-Activity Relationships of
Nitroaromatic Compounds to Four Aquatic
Organisms		 Chemosphere 34 (8) 1997 2022/07/21
甲殻類 Daphnia magna Intoxication/Immobile EC50 24 hours 12 Formulation × 16 ECOTOX Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4) 1998 2022/09/15
甲殻類 Daphnia sp. immobilization EC50 48 hours 3.2 mg/L nominal 14 BUA Report Canton JH, Slooff W, Kool HJ, Struvs J, Pouw TJM,
Wegman RCC, Piet GJ		 Toxicity, biodegradability and accumulation of a
number of Cl/N-containing compounds for
classification and establishing water quality
criteria		 Regul Toxicol Pharm 5 1985 2023/01/31
甲殻類 Daphnia magna EC50 48 hours 3.2 mg/L × 4 OECD SIDS (HPVC) 3 Canton, J.H. et al. Regul. Toxicol. Pharmacol. 5 1985 2023/01/18
甲殻類 Daphnia magna EC50 48 hours 23.9 mg/L 4 OECD SIDS (HPVC) 2 Deneer, J.W. et al. QSAR study of the toxicity of nitrobenzene
derivatives towards Daphnia magna, Chlorella
pyrenoidosa and Photobacterium
phosphoreum		 Aquatic Toxicology, 15 1989 2023/01/18
甲殻類 Daphnia magna Immobilization IC50 2 days 23800 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 D Deneer,J.W., C.J. Van Leeuwen, W. Seinen, J.L.
Maas-Diepeveen, and J.L.M. Hermens		 QSAR Study of the Toxicity of Nitrobenzene
Derivatives Towards Daphnia magna, Chlorella
pyrenoidosa and Photobacterium
phosphoreum		 Aquat. Toxicol.15 1989 2022/07/21
甲殻類 Daphnia magna EC50 48 hours 23.9 mg/L nominal × 14 BUA Report Deneer JW,van Leeuwen CJ, Seinen W, Maas-
Diepeveen JL, Hermens JLM		 QSAR study of the toxicity of nitrobenzene
derivatives towards Daphnia manga, Chlorella
pyrenoidosa and Photobacterium
phosphoreum		 Aquat Toxicol 15 1989 2023/01/31
甲殻類 Daphnia magna Mortality/Mortality LC50 48 hours 24000 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
甲殻類 Daphnia magna EC50 24 hours 12 mg/L nominal 14 BUA Report Kühn R, Patterd M, Pernak KD, Winter A Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage für
die Bewertung der Umweltverträglichkeit in
aquatischen Systemen		 UFOPLAN Nr. 10603052 des BMU, März 1988 1988 2023/02/21
甲殻類 Daphnia magna Mortality/Mortality LC50 48 hours 49 Active ingredient × 16 ECOTOX Canton,J.H., W. Slooff, H.J. Kool, J. Struys, T.J.
M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability, and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul. Toxicol. Pharmacol.5 1985 2022/09/15
甲殻類 Daphnia magna Intoxication/Immobile EC50 48 hours 3.2 Active ingredient × 16 ECOTOX Canton,J.H., W. Slooff, H.J. Kool, J. Struys, T.J.
M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability, and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul. Toxicol. Pharmacol.5 1985 2022/09/15
甲殻類 Daphnia magna reproduction NOEC 21 days 4 mg/L nominal test mat. ○ 12 ECHA Information on Registered Substances 1 study report 1988 2022/08/10
甲殻類 Daphnia magna reproduction NOEC 21 days 3 mg/L meas. test mat. ○ 12 ECHA Information on Registered Substances 1 secondary source 2001 2022/08/10
甲殻類 Daphnia magna reproduction NOEC 21 days 3 mg/L ○ 4 OECD SIDS (HPVC) 1 Kuehn, R. et al. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fuer
die Bewertung der Umweltvertraeglichkeit
in aquatischen Systemen		 UFOPLAN Nr. 106 03 052 des BMU, Maerz 1988 2023/01/18
甲殻類 Daphnia magna reproduction NOEC 21 days 3 mg/L meas. test mat. ○ 12 ECHA Information on Registered Substances 1 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
甲殻類 Daphnia magna intrinsic rate of natural increase NOEC 21 days 1.8 mg/L nominal 14 BUA Report Maas-Diepeveen JL, van Leeuwen CJ Aquatic toxicity of aromatic nitro compounds and
anillines to several freshwater species		 Laboratory for Ecotoxicology, Institute for
Inland Water Management and Waste Water
Treatment, Report No. 86-42		 1986 2023/01/31
甲殻類 Daphnia magna Reproduction/Time to first progeny NOEC 21 days 3 Active ingredient ○ 16 ECOTOX Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4) 1998 2022/09/15
甲殻類 Daphnia magna Reproduction NOEC 21 days 10000 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 D Maas-Diepeveen, J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Laboratory for Ecotoxicology, Institute for
Inland Water Management and Waste Water
Treatment, Report No.86-42		 1986 2022/07/21
甲殻類 Daphnia magna Reproduction NOEC 21 days 3000 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Kühn, R., M. Pattard, K.-D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res. 23(4) 1989 2022/07/21
甲殻類 Daphnia magna reproduction LOEC 21 days 9.9 mg/L 4 OECD SIDS (HPVC) 2 Deneer, J.W. et al. QSAR study of the toxicity of nitrobenzene
derivatives towards Daphnia magna, Chlorella
pyrenoidosa and Photobacterium
phosphoreum		 Aquatic Toxicology, 15 1989 2023/01/18
甲殻類 Daphnia magna Mortality/Mortality LC50 21 days 10700 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
甲殻類 Daphnia magna Reproduction/Reproduction, general NOEC 21 days 3 Active ingredient ○ 16 ECOTOX Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4) 1998 2022/09/15
甲殻類 Daphnia magna Mortality/Mortality NOEC 21 days 3 Active ingredient ○ 16 ECOTOX Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4) 1998 2022/09/15
甲殻類 Daphnia magna mortality, reproduction NOEC 504 hours 3 mg/L 9 ECETOC Aquatic Toxicity, EAT Kuhn, R., M. Pattard, K.-D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res. 23(4) (OECDG Data File) 1989 2022/07/21
甲殻類 Daphnia magna reproduction NOEC 21 days 3 mg/L effective 14 BUA Report Kühn R, Patterd M, Pernak KD, Winter A Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage für
die Bewertung der Umweltverträglichkeit in
aquatischen Systemen		 UFOPLAN Nr. 10603052 des BMU, März 1988 1988 2023/02/21
魚類 Danio rerio behaviour LOEC 14 days 5.91 mg/L meas. test mat. ○ 12 ECHA Information on Registered Substances 1 study report 1990 2022/08/10
魚類 Danio rerio mortality LC50 96 hours 34.8 mg/L nominal test mat. ○ 12 ECHA Information on Registered Substances 1 study report 1990 2022/08/10
魚類 Danio rerio NOEC 14 days 3.13 mg/L nominal test mat. ○ 12 ECHA Information on Registered Substances 1 OECD 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS
Initial Assessment Report		 UNEP publications 2001 2022/08/10
魚類 Leuciscus idus (Orfe) LC100 24 hours 10 mg/L × × 4 OECD SIDS (HPVC) 3 Bayer AG Internal studies: 1. Geschlossener Flaschen-Test
(1977), 2. Test on Leuciscus idus (1974), Oxygen
consumption inhibition test according to
Robra		 2022/06/08
魚類 Danio rerio mortality LC50 7 days 14 mg/L × 12 ECHA Information on Registered Substances 2 study report 1986 2022/08/10
魚類 Poecilia reticulata mortality LC50 96 hours 30 mg/L × 12 ECHA Information on Registered Substances 3 Canton JH, Slooff W, Kool HJ, Struys J, Gouw TJM,
Wegman RCC, Piet GJ. 		Toxicity, biodegrability and accumulation of a
number of Cl/N-containing compounds for
classification and establishing Water
Quality Criteria		 Regul. Toxicol. Pharmacol. 5: 123-131 1985 2022/08/10
魚類 Leuciscus idus LC100 24 hours 10 mg/L × 12 ECHA Information on Registered Substances 3 study report 1974 2022/08/10
魚類 Poecilia reticulata Mortality/Mortality LC50 14 days 30100 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
魚類 Danio rerio NOEC 14 days 2.9 mg/L meas. test mat. ○ 12 ECHA Information on Registered Substances 1 study report 1990 2022/08/10
魚類 Danio rerio Mortality/Mortality LC50 7 days 14000 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
魚類 Pimephales promelas Development/Normal MATC Until hatch 375 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Danio rerio (Zebrafish) LC50 96 hours 34.8 mg/L ○ 4 OECD SIDS (HPVC) 1 Roederer, G. Testung wassergefaehrdender Stoffe als Grundlage
fuer Wasserqualitaetsstandards		 Fraunhofer-Institut fuer Umweltchemie und
Oekotoxikologie, 5948 Schmallenberg, UFOPLAN-Nr.
116 08 071/01, 79 p		 1990 2023/02/08
魚類 Cyprinus carpio (Carp) LC50 96 hours 25.5 mg/L nominal × 14 BUA Report Zhao YH, Yuan X, Ji GD, Sheng LX Quantitative structure-activity relationships of
nitroaromatic compounds to four aquatic
organisms		 Chemosphere 34 1997 2023/01/31
魚類 Lepomis macrochirus (Bluegill) LC50 96 hours 0.55 mg/L 18 その他 CERI ハザードデータ集 1999 2025/05/08
魚類 Danio rerio (Zebrafish) feeding bihavior NOEC 14 days 2.9 mg/L effective ○ 14 BUA Report Roederer G Testung wasserfgefährdender Stoffe als Grundlage
für Wasser-qualitätsstandars		 Fraunfoher-Institut für Umweltchemie und
Ökotoxikologie, 5984 Schmallenberg, UFOPLAN-Nr.
116 08 071/01		 1990 2023/01/31
魚類 Oryzias latipes (Japanese medaka) LC50 48 hours 28 mg/L 4 OECD SIDS (HPVC) 2 MITI Biodegradation and Bioaccumulation: Data of
Existing Chemicals Based on the CSCL Japan,
Compiled under the Supervision of
Chemical Products Safety Division,
Basic Industries Bureau
MITI, Ed. by CITI,
October 1992		 Published by Japan Chemical Industry Ecology-
Toxicology & Information Center		 1992 2022/06/08
魚類 Danio rerio (Zebrafish) LC50 96 hours 34.8 mg/L effective ○ 14 BUA Report Roederer G Testung wasserfgefährdender Stoffe als Grundlage
für Wasser-qualitätsstandars		 Fraunfoher-Institut für Umweltchemie und
Ökotoxikologie, 5984 Schmallenberg, UFOPLAN-Nr.
116 08 071/01		 1990 2023/01/31
魚類 Poecilia reticulata (Guppy) LC50 96 hours 30 mg/L nominal 14 BUA Report Canton JH, Slooff W, Kool HJ, Struvs J, Pouw TJM,
Wegman RCC, Piet GJ		 Toxicity, biodegradability and accumulation of a
number of Cl/N-containing compounds for
classification and establishing water quality
criteria		 Regul Toxicol Pharm 5 1985 2023/01/31
魚類 Danio rerio Reproduction/Reproduction, general EC50 7 days 14000 Active ingredient × 16 ECOTOX Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment		 1986 2022/09/15
魚類 Danio rerio (Zebrafish) feeding behaviour LOEC 14 days 5.9 mg/L ○ 4 OECD SIDS (HPVC) 1 Roederer, G. Testung wassergefaehrdender Stoffe als Grundlage
fuer Wasserqualitaetsstandards		 Fraunhofer-Institut fuer Umweltchemie und
Oekotoxikologie, 5948 Schmallenberg, UFOPLAN-Nr.
116 08 071/01, 79 p		 1990 2023/02/08
魚類 Poecilia reticulata (Guppy) LC50 96 hours 30 mg/L × 4 OECD SIDS (HPVC) 3 Canton, J.H. et al. Regul. Toxicol. Pharmacol. 5 1985 2023/01/18
魚類 Pimephales promelas Development/Normal NOEC Until hatch 264 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Leuciscus idus (Orfe) LC0 24 hours 5 mg/L × × 4 OECD SIDS (HPVC) 3 Bayer AG Internal studies: 1. Geschlossener Flaschen-Test
(1977), 2. Test on Leuciscus idus (1974), Oxygen
consumption inhibition test according to
Robra		 2022/06/08
魚類 Poecilia reticulata (Guppy) LC50 14 days 30 mg/L ○ 4 OECD SIDS (HPVC) 2 Deneer, J.W. et al. Quantitative structure-activity relationships for
the toxicity and bioconcentration factor of
nitrobenzene derivatives towards the guppy
(Poecilia reticulata)		 Aquatic Toxicology, 10 1987 2023/01/18
魚類 Danio rerio (Zebrafish) mortality LOEC 14 days 24.8 mg/L ○ 4 OECD SIDS (HPVC) 1 Roederer, G. Testung wassergefaehrdender Stoffe als Grundlage
fuer Wasserqualitaetsstandards		 Fraunhofer-Institut fuer Umweltchemie und
Oekotoxikologie, 5948 Schmallenberg, UFOPLAN-Nr.
116 08 071/01, 79 p		 1990 2023/02/08
魚類 Pimephales promelas Development/Normal LOEC Until hatch 534 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Danio rerio (Zebrafish) feeding behaviour NOEC 14 days 2.9 mg/L ○ 4 OECD SIDS (HPVC) 1 Roederer, G. Testung wassergefaehrdender Stoffe als Grundlage
fuer Wasserqualitaetsstandards		 Fraunhofer-Institut fuer Umweltchemie und
Oekotoxikologie, 5948 Schmallenberg, UFOPLAN-Nr.
116 08 071/01, 79 p		 1990 2023/02/08
魚類 Cyprinus carpio (Carp) LC50 96 hours 25.5 mg/L 4 OECD SIDS (HPVC) 2 Zhao, Y.-H. et al. Quantitative Structure-Activity Relationships of
Nitroaromatic compounds to Four Aquatic
Organisms		 Chemosphere, Vol. 34, 8 1997 2023/01/18
魚類 Pimephales promelas mortality NOEC 33 days 2.07 mg/L ○ 12 ECHA Information on Registered Substances 2 Call, D.J. and Geiger, D.L. Subchronic toxicities of/industrial and
agricultural chemicals to Fathead
Minnows/(Pimephales promelas) Vol. I		 Center for Lake Superior/Environmental Studies,
Lake Superior Research Institute,/University of
Wisconsin-Superior, USA		 1992 2022/08/10
魚類 Pimephales promelas larval development NOEC 33 days 0.264 mg/L ○ 12 ECHA Information on Registered Substances 2 Call, D.J. and Geiger, D.L. Subchronic toxicities of/industrial and
agricultural chemicals to Fathead
Minnows/(Pimephales promelas) Vol. I		 Center for Lake Superior/Environmental Studies,
Lake Superior Research Institute,/University of
Wisconsin-Superior, USA		 1992 2022/08/10
魚類 Pimephales promelas Mortality/Survival NOEC 33 days 2070 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Length NOEC 33 days 534 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Weight LOEC 33 days 2070 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Mortality/Survival LOEC 33 days 3950 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Weight LOEC 33 days 2070 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Weight MATC 33 days 1460 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas weight NOEC 33 days 1.03 mg/L ○ 12 ECHA Information on Registered Substances 2 Call, D.J. and Geiger, D.L. Subchronic toxicities of/industrial and
agricultural chemicals to Fathead
Minnows/(Pimephales promelas) Vol. I		 Center for Lake Superior/Environmental Studies,
Lake Superior Research Institute,/University of
Wisconsin-Superior, USA		 1992 2022/08/10
魚類 Pimephales promelas Growth/Weight MATC 33 days 1460 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas larval development NOEC 33 days 0.264 mg/L ○ 12 ECHA Information on Registered Substances 2 secondary source 2001 2022/08/10
魚類 Pimephales promelas (Fathead minnow) weight and length of juveniles NOEC 33 days 1.02 mg/L ○ 4 OECD SIDS (HPVC) 2 Call, D.J. and Geiger, D.L. Subchronic toxicities of industrial and
agricultural chemicals to Fathead Minnows
(Pimephales promelas) Vol. I		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/02/20
魚類 Pimephales promelas (Fathead minnow) proportion surviving NOEC 33 days 2.1 mg/L effective ○ 14 BUA Report Call DJ and Geiger DL Subchronic toxicities of industrial and
agricultural chemicals to fathead minnows
(Pimephales promelas) Vol. Ⅰ		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/01/31
魚類 Pimephales promelas Growth/Weight NOEC 33 days 1030 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Length MATC 33 days 742 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Length LOEC 33 days 1030 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Mortality/Survival MATC 33 days 2860 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas Growth/Weight NOEC 33 days 1030 Active ingredient ○ 16 ECOTOX Call,D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI		 1992 2022/09/15
魚類 Pimephales promelas (Fathead minnow) proportion of normally developed larvae
/ total number of larvae hatched		 NOEC 4～5 days 0.26 mg/L effective ○ 14 BUA Report Call DJ and Geiger DL Subchronic toxicities of industrial and
agricultural chemicals to fathead minnows
(Pimephales promelas) Vol. Ⅰ		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/01/31
魚類 Pimephales promelas (Fathead minnow) length NOEC 33 days 0.53 mg/L effective ○ 14 BUA Report Call DJ and Geiger DL Subchronic toxicities of industrial and
agricultural chemicals to fathead minnows
(Pimephales promelas) Vol. Ⅰ		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/01/31
魚類 Pimephales promelas (Fathead minnow) weight NOEC 33 days 1 mg/L effective ○ 14 BUA Report Call DJ and Geiger DL Subchronic toxicities of industrial and
agricultural chemicals to fathead minnows
(Pimephales promelas) Vol. Ⅰ		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/01/31
魚類 Pimephales promelas (Fathead minnow) weight and length of juveniles LOEC 33 days 2.04 mg/L ○ 4 OECD SIDS (HPVC) 2 Call, D.J. and Geiger, D.L. Subchronic toxicities of industrial and
agricultural chemicals to Fathead Minnows
(Pimephales promelas) Vol. I		 Center for Lake Superior Environmental Studies,
Lake Superior Research Institute, University of
Wisconsin-Superior, USA		 1992 2023/02/20
魚 類 Oryzias latipes Mortality LC50 2 days 28000 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 D 通商産業省 o-クロロニトロベンゼンの濃縮度試験成績報告書 1976 2022/07/21
魚 類 Danio rerio Mortality LC50 4 days 34600 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Roderer, G. Testung Wassergefahrdender Stoffe als Grundlage
fur Wasserqualitatsstandards		 Testbericht: Wassergefahrdende Stoffe, Fraunhofer-
Institut fur Umweltchemie und Okotoxikologie,
Schmallenberg		 1990 2022/07/21
魚 類 Oryzias latipes Mortality LC50 2 days 30000 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Canton, J.H., W. Slooff, H.J. Kool, J. Struys, Th.
J.M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul.Toxicol.Pharmacol.5 1985 2022/07/21
魚 類 Cyprinus carpio Mortality LC50 4 days 25500 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 B Zhao, Y., X.Yuan, G. Ji G and L. Sheng Quantitative Structure-Activity Relationships of
Nitroaromatic Compounds to Four Aquatic
Organisms		 Chemosphere 34 (8) 1997 2022/07/21
魚 類 Pimephales promelas growth NOEC 33 days 534 µg/L 6 日本環境省　
化学物質の環境リスク評価（生態リスク初期評価）		 A Call, D.J., and D.L. Geiger Subchronic Toxicities of Industrial and
Agricultural Chemicals to Fathead Minnows
(Pimephales promelas). Volume I		 Ctr.for Lake Superior Environ.Stud., Univ.of
Wisconsin-Superior, Superior, WI		 1992 2022/07/21