生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 95-51-2
官報公示整理番号　METI No. ： 3-194
物質名 test material ： ｏ－クロロアニリン　／o-Chloroaniline
水溶解度 water solubility ： 8160mg/L (推計値 estimated)
LogKow ： 1.9 (実測値 measured)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Scenedesmus subspicatus Population NOEC >=250000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Nendza,M., and A. Wenzel Discriminating Toxicant Classes by Mode of Action
1. (Eco)toxicity Profiles		 Environ. Sci. Pollut. Res.13(3): 192-203 2006 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 2 days 90000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 3 days 40000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 3 days 150000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 4 days 35000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
藻類 Scenedesmus subspicatus Population EC50 2 days 235000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., and M. Pattard Results of the Harmful Effects of Water
Pollutants to Green Algae (Scenedesmus
subspicatus) in the Cell
Multiplication Inhibition
Test		 Water Res.24(1): 31-38 1990 2016/03/25
甲殻類 Daphnia magna Physiology EC50 2 days 1800 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Selected Water
Pollutants (Anilines, Phenols, Aliphatic
Compounds) to Daphnia magna		 Water Res.23(4): 495-499 1989 2016/03/25
甲殻類 Daphnia magna Physiology EC50 2 days 450 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Pedersen,F., E. Bjornestad, T. Vulpius, and H.B.
Rasmussen		 Immobilisation Test of Aniline Compounds with the
Crustacean Daphnia magna		 Proj.No.303587, Report to the Danish EPA,
Copenhagen, Denmark:93 p.		 1998 2016/03/25
甲殻類 Daphnia magna Behavior NOEC 21 days 32 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Reproduction NOEC 21 days 32 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4): 501-510 1989 2016/03/25
甲殻類 Daphnia magna Mortality LC50 2 days 130 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment:10 p.		 1986 2016/03/25
甲殻類 Daphnia magna Physiology EC50 1 days 6000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Water
Pollutants to Daphnia magna in the 21 Day
Reproduction Test		 Water Res.23(4): 501-510 1989 2016/03/25
甲殻類 Daphnia magna Behavior EC0 1 days 1400 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Mortality LC50 2 days 1500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Canton,J.H., W. Slooff, H.J. Kool, J. Struys, Th.
J.M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability, and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul. Toxicol. Pharmacol.5:123-131 1985 2016/03/25
甲殻類 Daphnia magna Physiology EC50 2 days 460 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Canton,J.H., W. Slooff, H.J. Kool, J. Struys, Th.
J.M. Pouw, R.C.C. Wegman, and G.J. Piet		 Toxicity, Biodegradability, and Accumulation of a
Number of Cl/N-Containing Compounds for
Classification and Establishing Water Quality
Criteria		 Regul. Toxicol. Pharmacol.5:123-131 1985 2016/03/25
甲殻類 Daphnia magna Physiology EC50 1 days 1700 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Pedersen,F., E. Bjornestad, T. Vulpius, and H.B.
Rasmussen		 Immobilisation Test of Aniline Compounds with the
Crustacean Daphnia magna		 Proj.No.303587, Report to the Danish EPA,
Copenhagen, Denmark:93 p.		 1998 2016/03/25
甲殻類 Daphnia magna Physiology EC50 1 days 4200 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Selected Water
Pollutants (Anilines, Phenols, Aliphatic
Compounds) to Daphnia magna		 Water Res.23(4): 495-499 1989 2016/03/25
甲殻類 Daphnia magna Behavior EC50 1 days 6000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Kuhn,R. Schadstoffwirkungen von Umweltchemikalien im
Daphnien-Reproduktions-Test als Grundlage fr die
Bewertung der Umweltgefhrlichkeit in
Aquatischen Sys		 Forschungsbericht 10603052, Mrz: 1988 2016/03/25
甲殻類 Daphnia magna Intoxication ET50 24 hours 8.62 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Urrestarazu Ramos, E. Aquatic toxicity of polar narcotic pollutants/
Mechanism, modeling and environmental effect
assessment (PhD Thesis)		 1998 2016/02/08
甲殻類 Daphnia magna Mortality LC50 48 hours 0.824 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Peter C. von der Ohe, Ralph Kühne, Ralf-Uwe Ebert,
Rolf Altenburger, Matthias Liess, and Gerrit
Schüürmann		 Structural Alerts-A New Classification Model to
Discriminate Excess Toxicity from Narcotic
Effect Levels of Organic Compounds in the
Acute Daphnid Assay		 2005 2016/02/08
甲殻類 Daphnia magna Intoxication ET50 24 hours 5.97 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Urrestarazu Ramos, E. Aquatic toxicity of polar narcotic pollutants/
Mechanism, modeling and environmental effect
assessment (PhD Thesis)		 1998 2016/02/08
甲殻類 Daphnia magna Lethal NOEC 504 hours 0.032 mg/L 9 ECETOC Aquatic Toxicity, EAT Kühn ea 89 2016/02/08
甲殻類 Daphnia magna Lethal LOEC 504 hours 0.101 mg/L 9 ECETOC Aquatic Toxicity, EAT Kühn ea 89 2016/02/08
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5680 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Geiger,D.L., S.H. Poirier, L.T. Brooke, and D.J.
Call		 Acute Toxicities of Organic Chemicals to Fathead
Minnows (Pimephales promelas) Volume III		 Center for Lake Superior Environmental Studies,
University of Wisconsin, Superior, WI:328 p.		 1986 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC0 2 days 14500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Lysak,A., and J. Marcinek Multiple Toxic Effect of Simultaneous Action of
Some Chemical Substances on Fish		 Rocz. Nauk Roln. Ser. H Rybactwo.94(3): 53-63 1972 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality 17.3 hours 1660 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bradbury,S.P., T.R. Henry, G.J. Niemi, R.W.
Carlson, and V.M. Snarski		 Use of Respiratory-Cardiovascular Responses of
Rainbow Trout (Salmo gairdneri) in Identifying
Acute Toxicity Syndromes in Fish: Part 3.
Polar Narcotics		 Environ. Toxicol. Chem.8(3): 247-261 1989 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5130 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Broderius,S.J., M.D. Kahl, and M.D. Hoglund Use of Joint Toxic Response to Define the Primary
Mode of Toxic Action for Diverse Industrial
Organic Chemicals		 Environ. Toxicol. Chem.14(9): 1591-1605 1995 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Physiology 17.3 hours 1660 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Bradbury,S.P., T.R. Henry, G.J. Niemi, R.W.
Carlson, and V.M. Snarski		 Use of Respiratory-Cardiovascular Responses of
Rainbow Trout (Salmo gairdneri) in Identifying
Acute Toxicity Syndromes in Fish: Part 3.
Polar Narcotics		 Environ. Toxicol. Chem.8(3): 247-261 1989 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5650 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Broderius,S.J., M.D. Kahl, and M.D. Hoglund Use of Joint Toxic Response to Define the Primary
Mode of Toxic Action for Diverse Industrial
Organic Chemicals		 Environ. Toxicol. Chem.14(9): 1591-1605 1995 2016/03/25
魚類 Poecilia reticulata (Guppy) Mortality LC50 14 days 6300 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Maas-Diepeveen,J.L., and C.J. Van Leeuwen Aquatic Toxicity of Aromatic Nitro Compounds and
Anilines to Several Freshwater Species		 Report No.86-42, Laboratory for Ecotoxicology,
Institute for Inland Water Management and Waste
Water Treatment:10 p.		 1986 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) Mortality LC100 2 days 121500 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Lysak,A., and J. Marcinek Multiple Toxic Effect of Simultaneous Action of
Some Chemical Substances on Fish		 Rocz. Nauk Roln. Ser. H Rybactwo.94(3): 53-63 1972 2016/03/25
魚類 Danio rerio (Zebrafish) Mortality LC50 4 days 41 μmol/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Zok,S., G. Gorge, W. Kalsch, and R. Nagel Bioconcentration, Metabolism and Toxicity of
Substituted Anilines in the Zebrafish
(Brachydanio rerio)		 Sci. Total Environ.109/110:411-421 1991 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5810 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information
REtrieval)		 Brooke,L.T., D.J. Call, D.L. Geiger, and C.E.
Northcott		 Acute Toxicities of Organic Chemicals to Fathead
Minnows (Pimephales promelas), Vol. 1		 Center for Lake Superior Environmental Studies,
University of Wisconsin-Superior, Superior, WI:
414 p.		 1984 2016/03/25
魚類 Poecilia reticulata (Guppy) Mortality LC50 96 hours 6.25 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Raevsky, O.A., and Dearden, J.C. Creation of predictive models of aquatic toxicity
of environmental pollutants with different
mechanisms of action on the basis of molecular
similarity and hybot descriptors.		 2004 2016/02/08
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 96 hours 5.7 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Russom, C.L., Bradbury, S.P., Broderius, S.J.,
Drummond, R.A. and Hammermeister, D.E.		 PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL
STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW
(PIMEPHALES PROMELAS)		 1997 2016/02/08
魚類 Oryzias latipes (Japanese medaka) Mortality LC50 48 hours 6.25 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) - Biodegradation and Bioaccumulation Data of
Existing Chemicals Based on the CSCL Japan		 1992 2016/02/08