生態影響に係る有害性情報


CAS登録番号 CAS RN ® ： 98-54-4
官報公示整理番号　METI No. ： 3-503
物質名 test material ： ４－ｔｅｒｔ－ブチルフェノール　／4-tert-Butylphenol
水溶解度 water solubility ： 580mg/L (推計値 estimated)
LogKow ： 3.31 (実測値 measured)
備考 remarks ：
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【注意事項】
* 生態影響に係る有害性情報更新日が2019年9月以前はRead-acrossデータに○を記載しておらず、被験物質が標記の物質ではない可能性がある。
**各情報源における信頼性評価スコアの定義は下記のとおりである。

OECD SIDS (HPVC) / EU Risk Assessment Report (EUリスク評価書） / ECHA Information on Registered Substances 1:信頼性あり 2:条件付きで信頼性あり 3:信頼性なし　4:情報が少なく評価不能
日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A：試験は信頼できる　B：試験は条件付きで信頼できる　C：試験の信頼性は低い　D：信頼性の判定不可　E：信頼性は低くないと考えられるが、原著にあたって確認したものではない
USEPA Pesticide Ecotoxicity Database Core:信頼性あり　Supplemental:条件付きで信頼性あり　Invalid:信頼性なし
生物種 学名 影響内容 エンドポイント 暴露期間(値) 暴露期間(単位) 毒性値 毒性値(単位) 毒性値(単位)種別 試験中の
被験物質
濃度測定
あり：○
なし：×		 情報源 情報源による
信頼性評価**		 著者 タイトル 記載誌 発行年 情報更新日
subject type scientific name effect endpoint exposure
duration
value		 exposure
duration
unit		 toxicity value toxicity unit toxicity unit type Read-across* QSAR GLP measurement
of the test
material		 original work type original work
reliability rank		 author title referenced journal publication year Information
update date
藻類 Pseudokirchneriella subcapitata Growth　(RATE) EC50 3 days 36300 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B （独）国立環境研究所 平成25 年度 化学物質環境リスク初期評価等実施業務報告書 2014 2016/03/07
藻類 Selenastrum capricornutum biomass EC50 72 hours 22.7 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Huels AG 1985 2016/03/03
藻類 Selenastrum capricornutum 生長阻害　生長速度 EC50 48 hours 30.3 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Pseudokirchneriella subcapitata Growth　(RATE) EC50 3 days 14000 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B - Exp Key Toxicity to aquatic algae and cyanobacteria.001. (2014.11.17 現在) European Chemical Agency：Information on Registered Substances, 4-tert-Butylphenol. 2001 2016/03/07
藻類 Selenastrum capricornutum 生長阻害　バイオマス EC50 72 hours 22.7 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Selenastrum capricornutum EC50 72 hours 14 mg/L ○ 7 EU Risk Assessment Report (EUリスク評価書） NIVA Test report for 4- tert butylphenol, growth inhibition of green alga Selenastrum capricornutum, Study number G023/2, (2001 b) 2001 2016/03/03
藻類 Selenastrum capricornutum 生長阻害　生長速度 EC50 72 hours 31.1 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Selenastrum capricornutum バイオマス EC50 72 hours 22.7 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
藻類 Selenastrum sp. Selenastrum capricornutum ATCC 22662 biomass EC50 72 hours 22.7 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
藻類 Selenastrum capricornutum NOEC 72 hours 0.32 mg/L ○ 7 EU Risk Assessment Report (EUリスク評価書） NIVA Test report for 4- tert butylphenol, growth inhibition of green alga Selenastrum capricornutum, Study number G023/2, (2001 b) 2001 2016/03/03
藻類 Selenastrum capricornutum biomass NOEC 72 hours 9.53 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Huels AG 1985 2016/03/03
藻類 Selenastrum capricornutum 生長阻害　生長速度 NOEC 72 hours 30.9 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Selenastrum capricornutum 生長阻害　バイオマス NOEC 72 hours 9.53 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Pseudokirchneriella subcapitata Growth　(RATE) NOEC 3 days 9530 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B （独）国立環境研究所 平成25 年度 化学物質環境リスク初期評価等実施業務報告書 2014 2016/03/07
藻類 Selenastrum capricornutum biomass LOEC 72 hours 17.2 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Huels AG 1985 2016/03/03
藻類 Pseudokirchneriella subcapitata Growth　(RATE) NOEC 3 days 320 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B - Exp Key Toxicity to aquatic algae and cyanobacteria.001. (2014.11.17 現在) European Chemical Agency：Information on Registered Substances, 4-tert-Butylphenol. 2001 2016/03/07
藻類 Pseudokirchneriella subcapitata Growth　(RATE) EC10 3 days 2900 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B - Exp Key Toxicity to aquatic algae and cyanobacteria.001. (2014.11.17 現在) European Chemical Agency：Information on Registered Substances, 4-tert-Butylphenol. 2001 2016/03/07
藻類 Selenastrum capricornutum 生長阻害　生長速度 NOEC 48 hours 30.9 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 平成5年度 環境汚染物質の生態影響調査結果報告書 (福島県、平成6年3月)* 1994 2016/03/10
藻類 Selenastrum capricornutum バイオマス NOEC 72 hours 9.53 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
藻類 Selenastrum capricornutum バイオマス LOEC 72 hours 17.2 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
藻類 Selenastrum sp. Selenastrum capricornutum ATCC 22662 biomass LOEC 72 hours 17.2 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
藻類 Selenastrum sp. Selenastrum capricornutum ATCC 22662 biomass NOEC 72 hours 9.53 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna Physiology EC50 1 days 4200 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Selected Water Pollutants (Anilines, Phenols, Aliphatic Compounds) to Daphnia magna Water Res.23(4): 495-499 1989 2016/03/25
甲殻類 Daphnia magna Physiology EC50 2 days 3900 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Kuhn,R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Selected Water Pollutants (Anilines, Phenols, Aliphatic Compounds) to Daphnia magna Water Res.23(4): 495-499 1989 2016/03/25
甲殻類 Daphnia magna Immobilization EC50 2 days 4800 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B - Exp Key Short-term toxicity to aquatic invertebrates.001. European Chemical Agency：Information on Registered Substances, 4-tert-Butylphenol. 2001 2016/03/07
甲殻類 Daphnia magna 遊泳阻害 EC50 48 hours 3.9 mg/L 8 NITE 化学物質の初期リスク評価書 Kuhn, R., Pattard, M., Pernak, K. and Winter A. Results of the harmful effects of selected water pollutants (anilines, phenols, aliphatic compounds) to Daphnia magna. Wat. Res. 23 (4) 1989 2016/03/10
甲殻類 Daphnia magna EC50 48 hours 6.7 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Environment Agency of Japan Toxicity Testing Reports of Environmental Chemicals, Vol. 4 (1996), cited in OECD SIDS Initial Assessment Profile. 1996 2016/03/03
甲殻類 Daphnia magna Immobilization EC50 2 days 6700 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B 環境庁 平成5 年度 生態影響試験 1994 2016/03/07
甲殻類 Daphnia magna EC50 48 hours 3.9 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Kühn R, Pattard M, Pernak KD, Winter A. Results of the harmful effects of selected water pollutants (anilines, phenols, aliphatic compounds) to Daphnia magna. Wat Res 23(4) 1989 2016/03/03
甲殻類 Daphnia magna EC50 24 hours 7.3 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna EC50 48 hours 4.8 mg/L ○ 7 EU Risk Assessment Report (EUリスク評価書） NIVA Test report, effect of 4- tert butylphenol on the immobilisation of Daphnia magna, Study number G023/1, (2001 a) 2001 2016/03/03
甲殻類 Daphnia magna Immobilization EC50 2 days 3900 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B Kühn, R., M. Pattard, K.D. Pernak, and A. Winter Results of the Harmful Effects of Selected Water Pollutants (Anilines, Phenols, Aliphatic Compounds) to Daphnia magna. Water Res. (U.S.EPA「AQUIRE」) 1989 2016/03/07
甲殻類 Daphnia magna EC50 48 hours 6.7 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna EC0 48 hours 0.34 mg/L 11 Japan チャレンジプログラム Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res., 23 1989 2016/03/11
甲殻類 Daphnia magna 遊泳阻害 EC50 24 hours 7.3 mg/L 8 NITE 化学物質の初期リスク評価書 環境省 環境庁 (1994b) 平成5年 OECD高生産量化学物質生態影響検討調査 (岐阜県) 1994 2016/03/10
甲殻類 Daphnia magna EC50 24 hours 3.4 mg/L 11 Japan チャレンジプログラム Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res., 23 1989 2016/03/11
甲殻類 Daphnia magna 遊泳阻害 EC50 48 hours 6.7 mg/L 8 NITE 化学物質の初期リスク評価書 環境省 環境庁 (1994b) 平成5年 OECD高生産量化学物質生態影響検討調査 (岐阜県) 1994 2016/03/10
甲殻類 Daphnia magna EC50 48 hours 3.4 mg/L 11 Japan チャレンジプログラム Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res., 23 1989 2016/03/11
甲殻類 Daphnia magna Intoxication ET50 24 hours 4.23 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Urrestarazu Ramos, E. Aquatic toxicity of polar narcotic pollutants/ Mechanism, modeling and environmental effect assessment (PhD Thesis) 1998 2016/02/08
甲殻類 Daphnia magna Mortality LC50 48 hours 4.23 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Peter C. von der Ohe, Ralph Kühne, Ralf-Uwe Ebert, Rolf Altenburger, Matthias Liess, and Gerrit Schüürmann Structural Alerts-A New Classification Model to Discriminate Excess Toxicity from Narcotic Effect Levels of Organic Compounds in the Acute Daphnid Assay 2005 2016/02/08
甲殻類 Daphnia magna EC50 48 hours 3.4 mg/L × 4 OECD SIDS (HPVC) Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res 1989 2016/02/23
甲殻類 Daphnia magna EC50 24 hours 3.4 mg/L × 4 OECD SIDS (HPVC) Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res 1989 2016/02/23
甲殻類 Daphnia magna EC0 48 hours 0.34 mg/L × 4 OECD SIDS (HPVC) Kuhn, R., Pattard, M., Pernak, K.D. and Winter, A. Water Res 1989 2016/02/23
甲殻類 Daphnia magna EC50 48 hours 6.7 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna EC50 24 hours 7.3 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna reproduction LOEC 21 days 2.3 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna reproduction EC50 21 days 2 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna NOEC 21 days 0.73 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna LOEC 21 days 2.3 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna Reproduction NOEC 21 days 730 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B 環境庁 平成5 年度 生態影響試験 1994 2016/03/07
甲殻類 Daphnia magna reproduction LOEC 21 days 2.3 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Environment Agency of Japan Toxicity Testing Reports of Environmental Chemicals, Vol. 4 (1996), cited in OECD SIDS Initial Assessment Profile. 1996 2016/03/03
甲殻類 Daphnia magna reproduction EC50 21 days 2 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Environment Agency of Japan Toxicity Testing Reports of Environmental Chemicals, Vol. 4 (1996), cited in OECD SIDS Initial Assessment Profile. 1996 2016/03/03
甲殻類 Daphnia magna 遊泳阻害 NOEC 48 hours 2.6 mg/L 8 NITE 化学物質の初期リスク評価書 Kuhn, R., Pattard, M., Pernak, K. and Winter A. Results of the harmful effects of selected water pollutants (anilines, phenols, aliphatic compounds) to Daphnia magna. Wat. Res. 23 (4) 1989 2016/03/10
甲殻類 Daphnia magna EC50 21 days 2 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna reproduction NOEC 21 days 0.73 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Environment Agency of Japan Toxicity Testing Reports of Environmental Chemicals, Vol. 4 (1996), cited in OECD SIDS Initial Assessment Profile. 1996 2016/03/03
甲殻類 Daphnia magna 繁殖 LOEC 21 days 2.3 mg/L 8 NITE 化学物質の初期リスク評価書 環境省 環境庁 (1994b) 平成5年 OECD高生産量化学物質生態影響検討調査 (岐阜県) 1994 2016/03/10
甲殻類 Daphnia magna 繁殖 NOEC 21 days 0.73 mg/L 8 NITE 化学物質の初期リスク評価書 環境省 環境庁 (1994b) 平成5年 OECD高生産量化学物質生態影響検討調査 (岐阜県) 1994 2016/03/10
甲殻類 Daphnia magna NOEC 48 hours 3.2 mg/L ○ 7 EU Risk Assessment Report (EUリスク評価書） NIVA Test report, effect of 4- tert butylphenol on the immobilisation of Daphnia magna, Study number G023/1, (2001 a) 2001 2016/03/03
甲殻類 Daphnia magna NOEC 48 hours <1 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
甲殻類 Daphnia magna 繁殖 EC50 21 days 2 mg/L 8 NITE 化学物質の初期リスク評価書 環境省 環境庁 (1994b) 平成5年 OECD高生産量化学物質生態影響検討調査 (岐阜県) 1994 2016/03/10
甲殻類 Daphnia magna reproduction NOEC 21 days 0.73 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
甲殻類 Daphnia magna NOEC 48 hours <1 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
魚類 Cyprinus carpio (Carp) Cellular Effects 28 days 690～2300 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Oncorhynchus mykiss (Rainbow trout) No Group Code 3 hours 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Cyprinus carpio (Carp) Behavior 28 days 690～2300 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Mortality 2.13 days 134～200 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Loeb,H.A., and W.H. Kelly Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124 p. 1963 2016/03/25
魚類 Cyprinus carpio (Carp) Growth NOEC 28 days 2300 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Biochemical LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Biochemical LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Biochemical LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Mortality LC50 4 days 6900 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Lepomis macrochirus (Bluegill) No Group Code 3 hours 5000 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Applegate,V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC:157 p. 1957 2016/03/25
魚類 Cyprinus carpio (Carp) Biochemical LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Growth LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Growth LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Cyprinus carpio (Carp) Biochemical LOEC 28 days 690～2300 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth 4 days 5440 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Behavior 4 days 3100 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Cyprinus carpio (Carp) Growth LOEC 28 days 690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Barse,A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio Pestic. Biochem. Physiol.86(3): 172-179 2006 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 1 hours >6250～<8000 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 1 days 6210 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Growth 4 days 3100 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Behavior 4 days 1870 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 2 days 5690 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 3 days 5260 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5140 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas Environ. Pollut. A.35(4): 367-381 1984 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 1 days 6250 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 2.25 days >4500～<6250 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 3 days >4500～<6250 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5150 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 1.25 days 6250 μg/L 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 2 days >4500～<6250 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 3 hours >6250～<8000 16 US EPA AQUIRE (AQUatic toxicity Information REtrieval) Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:326 p. 1985 2016/03/25
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 96 hours 5.21 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Russom, C.L., Bradbury, S.P., Broderius, S.J., Drummond, R.A. and Hammermeister, D.E. PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS) 1997 2016/02/08
魚類 Oryzias latipes (Japanese medaka) LC50 72 hours 5.1 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
魚類 Oryzias latipes (Japanese medaka) LC50 48 hours 5.1 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 5.1 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
魚類 Oryzias latipes (Japanese medaka) LC100 24 hours 6.8 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 環境庁 (1994c) 平成5年度 環境汚染物質の生態影響調査結果報告書 (岡山県、平成6年3月) 1994 2016/03/11
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 5.1 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 環境庁 (1994c) 平成5年度 環境汚染物質の生態影響調査結果報告書 (岡山県、平成6年3月) 1994 2016/03/11
魚類 Pimephales promelas (Fathead minnow) LC50 24 hours 6.2 mg/L 11 Japan チャレンジプログラム Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. (Ser. A) 35 1984 2016/03/11
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 5.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Environment Agency of Japan The acute toxicity of selected substituted phenols, benzenes, and benzoic acid esters to fathead minnows, Pimpephales promelas. Toxicity Testing Reports of Environmental Chemicals, Vol. 4 (1996), cited in OECD SIDS Initial Assessment Profile. 1996 2016/03/03
魚類 Oryzias latipes (Japanese medaka) LC50 96 hours 5.1 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
魚類 Oryzias latipes (Japanese medaka) LC50 48 hours 5.1 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5150 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A Geiger, D.L., C.E. Northcott, D.J. Call, and L.T. Brooke Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume 2. Ctr.for Lake Superior Environ.Stud., Univ.of Wisconsin-Superior, Superior, WI :326 p. 1985 2016/03/07
魚類 Pimephales promelas (Fathead minnow) Mortality LC50 4 days 5140 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） A Holcombe, G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber The Acute Toxicity of Selected Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas. Environ.Pollut.Ser.A (U.S.EPA「AQUIRE」) 1984 2016/03/07
魚類 Oryzias latipes (Japanese medaka) LC50 24 hours 5.1 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
魚類 Oncorhynchus mykiss (Rainbow trout) LC50 96 hours >1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） SafePharm Laboratories Ltd. Acute Toxicity to Rainbow Trout. Report No. 47/1600 unpublished 1991 2016/03/03
魚類 Oryzias latipes (Japanese medaka) LC50 48 hours 4 mg/L 8 NITE 化学物質の初期リスク評価書 通商産業省 通商産業省 (1977) 通産省公報 (1977年11月30日) 製品評価技術基盤機構化学物質管理情報(http://www.nite.go.jpから引用) 1977 2016/03/10
魚類 Oryzias latipes (Japanese medaka) LC50 72 hours 5.1 mg/L × 11 Japan チャレンジプログラム 環境省 1995 2016/03/11
魚類 Pimephales promelas (Fathead minnow) LC50 72 hours 5.3 mg/L 11 Japan チャレンジプログラム Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. (Ser. A) 35 1984 2016/03/11
魚類 Cyprinus carpio (Carp) Mortality LC50 4 days 6900 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） D Barse, A.V., T. Chakrabarti, T.K. Ghosh, A.K. Pal, and S.B. Jadhao One-Tenth Dose of LC50 of 4-tert-Butylphenol Causes Endocrine Disruption and Metabolic Changes in Cyprinus carpio. Pestic.Biochem.Physiol. 2006 2016/03/07
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 5.14 mg/L 7 EU Risk Assessment Report (EUリスク評価書） Holcombe et al. The acute toxicity of selected substituted phenols, benzenes, and benzoic acid esters to fathead minnows, Pimpephales promelas. Environ. Pollut. (Ser. A), 35 1984 2016/03/03
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 5.1 mg/L 11 Japan チャレンジプログラム Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. (Ser. A) 35 1984 2016/03/11
魚類 Pimephales promelas (Fathead minnow) LC50 48 hours 5.7 mg/L 11 Japan チャレンジプログラム Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. (Ser. A) 35 1984 2016/03/11
魚類 Oryzias latipes (Japanese medaka) Mortality LC50 4 days 5100 μg/L 6 日本環境省　化学物質の環境リスク評価（生態リスク初期評価） B 環境庁 平成5 年度 生態影響試験 1994 2016/03/07
魚類 Oryzias latipes (Japanese medaka) LC50 48 hours 4 mg/L 7 EU Risk Assessment Report (EUリスク評価書） MITI Biodegradation and Bioaccumulation Data of Existing Chemicals. Based on the CSCL Japan. Ministry of Trade and Industry, Japan. 1992 2016/03/03
魚類 Oryzias latipes (Japanese medaka) LC0 96 hours 3 mg/L 8 NITE 化学物質の初期リスク評価書 環境庁 環境庁 (1994c) 平成5年度 環境汚染物質の生態影響調査結果報告書 (岡山県、平成6年3月) 1994 2016/03/11
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 5.1 mg/L 8 NITE 化学物質の初期リスク評価書 Holcombe, G.W. et al. Environ. Pollut., (Ser. A), 35, 367 (EU: IUCLID, 2000から引用) 1984 2016/03/10
魚類 Poecilia reticulata (Guppy) Mortality LC50 96 hours 5.21 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) Raevsky, O.A., and Dearden, J.C. Creation of predictive models of aquatic toxicity of environmental pollutants with different mechanisms of action on the basis of molecular similarity and hybot descriptors. 2004 2016/02/08
魚類 Oryzias latipes (Japanese medaka) Mortality LC50 48 hours 4.04 mg/L 17 Aquatic OASIS (OECD QSAR Toolbox) - Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan 1992 2016/02/08
魚類 Pimephales promelas (Fathead minnow) LC50 24 hours 6.2 mg/L 4 OECD SIDS (HPVC) Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. 1984 2016/02/23
魚類 Pimephales promelas (Fathead minnow) LC50 72 hours 5.3 mg/L 4 OECD SIDS (HPVC) Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. 1984 2016/02/23
魚類 Pimephales promelas (Fathead minnow) LC50 48 hours 5.7 mg/L 4 OECD SIDS (HPVC) Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. 1984 2016/02/23
魚類 Pimephales promelas (Fathead minnow) LC50 96 hours 5.1 mg/L 4 OECD SIDS (HPVC) Holcombe G.W., Phipps, G.L., Knuth, M.L. and Felhaber, T. Environ. Pollut. 1984 2016/02/23
魚類 Oryzias latipes (Japanese medaka) LC50 24 hours 5.1 mg/L × 4 OECD SIDS (HPVC) Environment Agency of JAPAN 1995 2016/02/23
魚類 Cyprinus carpio (Carp) growth NOEC >0.256 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Gimeno et al. 1998 2016/03/03
魚類 Cyprinus carpio (Carp) Primordial germ cell NOEC <0.036 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Gimeno et al. 1998 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F0 survival & growth NOEC 60 days 0.402 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F1 length NOEC 61 days 0.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Pimephales promelas (Fathead minnow) delayed hatching, presence of intravascular fluid in female gonads and the presence of fatpads and fadpad score in male fish LOEC 82 μg/L 7 EU Risk Assessment Report (EUリスク評価書） OECD “Environmental Health and Safety Publication, Series on testing and Assessment” drafted a document (2004, October version) “Detailed review paper on fish screening assays for the detection of endocrine active substances OECD series on testing and assessment, Number 47. Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances, Appendix E. 2004 2016/03/03
魚類 Cyprinus carpio (Carp) Reproductive tract development NOEC <0.036 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Gimeno et al. 1998 2016/03/03
魚類 Pimephales promelas (Fathead minnow) Female condition factor NOEC <0.056 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Panter, G. H., Hutchinson, T. H., Hurd, K. S., Bamforth, J., Stanley, R. D., Duffell, S., Hargreaves, A., Gimeno, S. and Tyler, C. R. Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquat Toxicol 77 2006 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F1 sex ratio NOEC 61 days 0.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Oryzias latipes (Japanese medaka) male 2nd sexual characteristics: Dorsal fin length NOEC 28 days 0.01 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Hagino, S., Kagoshima, M. and Ashida, S. Effects of ethinylestradiol, diethylstilbestrol, 4-t pentylphenol, 17β-estradiol, methyltestosterone and flutamide on sex reversal in S-rR strain medaka (Oryzias latipes). Environemental Science 8 2001 2016/03/03
魚類 Cyprinus carpio (Carp) Formation of oviducts in male fish and reduced number of primordial germ cells in gonads NOEC >=0.14 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno, S., Komen, H., Venderbosch, P. W. M. and Bowmer, T. Disruption of sexual differentiation in genetic male common carp (Cyprinus carpio) exposed to an alkylphenol during different life stages. Environ. Sci. Technol. 31 1997 2016/03/03
魚類 Pimephales promelas (Fathead minnow) Wet weight and standard length NOEC 0.56 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Panter, G. H., Hutchinson, T. H., Hurd, K. S., Bamforth, J., Stanley, R. D., Duffell, S., Hargreaves, A., Gimeno, S. and Tyler, C. R. Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquat Toxicol 77 2006 2016/03/03
魚類 Pimephales promelas (Fathead minnow) delayed hatching, presence of intravascular fluid in female gonads and the presence of fatpads and fadpad score in male fish NOEC 25 μg/L 7 EU Risk Assessment Report (EUリスク評価書） OECD “Environmental Health and Safety Publication, Series on testing and Assessment” drafted a document (2004, October version) “Detailed review paper on fish screening assays for the detection of endocrine active substances OECD series on testing and assessment, Number 47. Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances, Appendix E. 2004 2016/03/03
魚類 Cyprinus carpio (Carp) Gonadosomatic index NOEC 90 days <0.032 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno et al. 1998 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F0 vitellogenin induction NOEC 101 days <0.0511 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F0 abnormal sex differentiation NOEC 101 days 0.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Pimephales promelas (Fathead minnow) Plasma vitellogenin induction NOEC 0.56 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Panter, G. H., Hutchinson, T. H., Hurd, K. S., Bamforth, J., Stanley, R. D., Duffell, S., Hargreaves, A., Gimeno, S. and Tyler, C. R. Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquat Toxicol 77 2006 2016/03/03
魚類 Cyprinus carpio (Carp) Spermatocrit NOEC 90 days 0.32 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno et al. 1998 2016/03/03
魚類 Cyprinus carpio (Carp) Testis histometry (diameter of seminiferous lobules) NOEC 90 days <0.032 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno et al. 1998 2016/03/03
魚類 Oryzias latipes (Japanese medaka) F0 reproductive impairment NOEC 101 days 0.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Seki m, Yokota H, Mastubara, H, Maeda M, Tadokoro, H & Kobayashi K Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes). Environ. Toxicol. Chem. 22 2003 2016/03/03
魚類 Cyprinus carpio (Carp) Weight and viscerosomatic index NOEC 90 days >1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno et al. 1998 2016/03/03
魚類 Pimephales promelas (Fathead minnow) Larval survival NOEC 0.56 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Panter, G. H., Hutchinson, T. H., Hurd, K. S., Bamforth, J., Stanley, R. D., Duffell, S., Hargreaves, A., Gimeno, S. and Tyler, C. R. Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquat Toxicol 77 2006 2016/03/03
魚類 Cyprinus carpio (Carp) Number of primordial germ cells NOEC 0.32 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno, S., Gerritsen, A., Bowmer, T. and Komen, H. Feminization of male carp. Nature 384 1996 2016/03/03
魚類 Cyprinus carpio (Carp) Vitellogenin induction NOEC 90 days 0.32 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno et al. 1998 2016/03/03
魚類 Cyprinus carpio (Carp) Vitellogenin induction NOEC 96 hours 3.285 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Smeets, J. M., van Holsteijn, I., Giesy, J. P., Seinen, W. and van den Berg, M. Estrogenic potencies of several environmental pollutants, as determined by vitellogenin induction in a carp hepatocyte assay. Toxicol Sci 50 1999 2016/03/03
魚類 Oryzias latipes (Japanese medaka) male 2nd sexual characteristics: Papillary processes on anal fin NOEC 28 days 0.001 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Hagino, S., Kagoshima, M. and Ashida, S. Effects of ethinylestradiol, diethylstilbestrol, 4-t pentylphenol, 17β-estradiol, methyltestosterone and flutamide on sex reversal in S-rR strain medaka (Oryzias latipes). Environemental Science 8 2001 2016/03/03
魚類 Oryzias latipes (Japanese medaka) male 2nd sexual characteristics: Anal fin length NOEC 28 days 0.01 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Hagino, S., Kagoshima, M. and Ashida, S. Effects of ethinylestradiol, diethylstilbestrol, 4-t pentylphenol, 17β-estradiol, methyltestosterone and flutamide on sex reversal in S-rR strain medaka (Oryzias latipes). Environemental Science 8 2001 2016/03/03
魚類 Cyprinus carpio (Carp) Percentage oviduct NOEC 0.1 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Gimeno, S., Gerritsen, A., Bowmer, T. and Komen, H. Feminization of male carp. Nature 384 1996 2016/03/03
魚類 Oryzias latipes (Japanese medaka) male 2nd sexual characteristics: Differentiation of male testes into ovaries NOEC 28 days 0.001 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 2 Hagino, S., Kagoshima, M. and Ashida, S. Effects of ethinylestradiol, diethylstilbestrol, 4-t pentylphenol, 17β-estradiol, methyltestosterone and flutamide on sex reversal in S-rR strain medaka (Oryzias latipes). Environemental Science 8 2001 2016/03/03
魚類 Pimephales promelas (Fathead minnow) Male secondary sexual characteristics NOEC 0.56 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Panter, G. H., Hutchinson, T. H., Hurd, K. S., Bamforth, J., Stanley, R. D., Duffell, S., Hargreaves, A., Gimeno, S. and Tyler, C. R. Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas). Aquat Toxicol 77 2006 2016/03/03
魚類 Cyprinus carpio (Carp) Vitellogenin induction NOEC 0.09 mg/L 7 EU Risk Assessment Report (EUリスク評価書） 1 Gimeno et al. 1998 2016/03/03
魚類 Cyprinus carpio (Carp) NOEL 44 hours 153 mg/ｋg、最高投与量 8 NITE 化学物質の初期リスク評価書 Loeb, H.A. and Kelly, W.H. Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp. Special Scientific Report - Fisheries No. 471. United States Department of the Interior, Fish and Wildlife Service, Washington D.C. 1963 2016/03/10